ΤΡΙΑΝΤΑΦΥΛΛΟΣ ΣΤΥΛΙΑΝΟΠΟΥΛΟΣ
ΣΤΥΛΙΑΝΟΠΟΥΛΟΣ ΤΡΙΑΝΤΑΦΥΛΛΟΣ
STYLIANOPOULOS TRIANTAFYLLOS
...
ΕΠΙΚΟΥΡΟΣ/Η ΚΑΘΗΓΗΤΗΣ/ΡΙΑ
Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής
Green Park
Λεωφ. Αγλαντζιας 91
507
+357 2289 2238
+357 2289 5081
www.ucy.ac.cy/cancer_biophysics/en

    Προσωπικό Προφίλ

    Diploma in Chemical Engineering, 2003
    National Technical University of Athens, Greece
     
    PhD in Chemical Engineering, 2008
    University of Minnesota, USA
     
    Postdoctoral training, Department of Radiation Oncology
    Massachusetts General Hospital / Harvard Medical School, USA
      
    Triantafyllos received a Diploma in Chemical Engineering from National Technical University of Athens, Greece (GPA: 9.34/10) in 2003. The same year he joined the Chemical Engineering graduate program at the University of Minnesota, USA to pursue his doctoral studies. He worked with Professor Victor Barocas on modeling the mechanical response of native and bioartificial tissues. During his doctoral studies, he was elected twice top doctoral student of the department. After the completion of his PhD., in May 2008, Triantafyllos worked as a postdoctoral fellow in Dr. Rakesh Jain's lab in the department of Radiation Oncology at Harvard Medical School and Massachusetts General Hospital, USA. In Dr. Jain's lab he performed research in a mixture of experimental and computational problems for optimizing the delivery of nanomedicine to solid tumors. In September 2010, he joined the faculty of the Mechanical and Manufacturing Engineering department at the University of Cyprus.
     
    Triantafyllos has co-authored over 90 publications published or accepted for publication in peer-review journals. His publication record includes four articles in Nature journals (Nature Nanotechnology, Nature Medicine, Nature Communications and Nature Reviews Clinical Oncology), seven in PNAS, and two in Cancer Research. h-index:29, > 5000 hetero-citations (Web-of-Science) | h-index:32, > 7500 citations (GoogleScholar).
     
    He has received a highly selective research grant by the European Research Council in 2013 as well as the prestigious Y. C. Fung Young Investigator award by the American Society of Mechanical Engineers in 2016 (https://www.asme.org/about-asme/participate/honors-awards/achievement-awards/y-c-fung-young-investigator-award). Triantafyllos was also the recipient of the 2014 Most Cited Paper Award by the Biomedical Enigneering Society (BMES) of the USA in 2014 and the New Researcher Award by the Research Promotion Foundation of Cyprus the same year.    
     
    Triantafyllos is a member of the American Society of Mechanical Engineers, the Biomedical Engineering Society of the USA, the European Foundation of Clinical Nanomedicine, the European Society of Biomechanics and the Greek Association of Computational Mechanics.
    The major focus of the current research is on the mechanics (solid and fluid) and drug delivery of solid tumors. I study the evolution of fluid and solid stresses in tumors and how these stresses correlate to tumors' patho-physiology. Furthermore, I investigate strategies to improve delivery of chemo- and nano-therapeutics to tumors by either modifying the tumor microenvironment or developing rules for the optimal design of therapeutic agents. Areas of interest include 1) development of therapeutic strategies to re-engineer solid tumors in order to improve therapy; 2) mathematical modeling of the fluid and solid mechanics of cancer; 3) investigation of specific genes that are related to cancer metastasis in relation to tumor stiffness; and 4) response of stromal cells to mechanical stimuli.  
     
    Current Funding ID:
     
    European Research Council (ERC) Starting Grant (ERC-2013-StG-336839 ReEngineeringCancer). Title: 'Re-engineering the tumor microenvironment to alleviate mechanical stresses and improve chemotherapy'. 1,440,360 Euros. January 2014 - December 2019.
     
    Marie-Curie International Reintegration Grant (PIRG08-GA-2010-276894 Cancer Nanomedicine). Grant Title: 'Optimizing the Delivery of Nanomedicine to Solid Tumors'. 100,000 Euros. August 2011- July 2015 (http://www.eng.ucy.ac.cy/cancernano/).
     
    Horizon 2020, Marie Skłodowska-Curie Individual Fellowship, (MSCA-IF-2014-657139 STROMAMECH). Grant Title: "Targeting stromal cells to modify tumor mechanical microenvironment and optimize drug delivery".  €151,649. May 2015 - April 2017.

    Horizon 2020, Marie Skłodowska-Curie Individual Fellowship, (MSCA-IF-2014-658769-MYO-DESMOPLASIA). Grant Title: "Modulating the behaviour of cancer myofibroblasts to control tumour desmoplasia".  €163,649. June 2015 - May 2017.

    Young Investigator Award, Research Promotion Foundation of Cyprus, €35,000. June 2015 - October 2016.

    For a detailed list please visit our website at www.ucy.ac.cy/cancer_biophysics/en/publications

    1.       V. Gkretsi, A. Stylianou, T. Stylianopoulos*, Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, b-catenin and urokinase-plasminogen activator (uPA), Experimental Cell Research, accepted, 2016.
    2.       V. Gkretsi, A. Stylianou, M. Louca, T. Stylianopoulos*, "Identification of Ras Suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach", Oncotarget, conditionally accepted, 2017.
    3.       C. Polydorou, F. Mpekris, P. Papageorgis, V. Voutouri, T. Stylianopoulos*, "Pirfenidone normalizes the tumor microenvironment to improve chemotherapy", Oncotarget, accepted, 2017.
    4.       S. Angeli, T. Stylianopoulos*, "Experimental measurements and mathematical modeling towards quantification of brain swelling stress", J. Biomechanics, accepted, 2017.
    5.       P. Papageorgis, C. Polydorou, F. Mpekris, C. Voutouri, E. Agathokleous, C. Kapnissi-Christodoulou, T. Stylianopoulos*, "Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nano-therapeutics in a size-dependent manner", Scientific Reports, accepted, 2017.
    6.       F. Mpekris, J.W. Baish, T. Stylianopoulos*, R. K. Jain, "Role of vascular normalization in benefit from metronomic chemotherapy: Insights from a mathematical model", PNAS, accepted, 2017.
    7.       A. Stylianou, V. Gkretsi, C. S. Patrickios, T. Stylianopoulos*, "Exploring the nano-surface of collagenous and other fibrotic tissues with AFM", Methods in Enzymology, accepted, 2016.
    8.       V. Vavourakis, P.A. Wijeratne, R. Shipley, M. Loizidou, T. Stylianopoulos, D. J. Hawkes, "A validated multiscale in-silico model for mechano-sensitive tumour angiogenesis and growth", PLoS Computational Biology, accepted, 2016.
    9.       C. Voutouri, C. Polydorou, P. Papageorgis, V. Gkretsi and T. Stylianopoulos*, "Hyaluronan-derived swelling of solid tumors, the contribution of collagen and cancer cells and implications for cancer therapy", Neoplasia, 18(12):732-741, 2016.
    10.   J.C.L. Alfonso, A. Köhn-Luque, T. Stylianopoulos, F. Feuerhake, A. Deutch, H. Hatzikirou. " Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights", Scientific Reports, 6:37283, 2016.
    11.   T. Stylianopoulos*. "The solid mechanics of cancer and strategies for improved therapy". Journal of Biomechanical Engineering (In Press), 2016.
    12.   D. Ambrosi, S. Pezzuto, D. Riccobelli, T. Stylianopoulos, C. Ciarletta, "Solid tumors are poroelastic solids with a chemo-mechanical feedback on growth", J. Elasticity, accepted, 2016.
    13.   Kitiri E., C. Patrickios, C. Voutouri, T. Stylianopoulos, I. Hoffmann, R. Schweins, and M. Gradzielski. "Synthesis and characterization of double-networks based on pH-responsive, amphiphilic "core-first" star first polymer conetworks prepared by sequential RAFT polymerization". Polymer Chemistry 8 (1), 245-259, 2016.
    14.   S. Aggeli and T. Stylianopoulos*,"Biphasic modeling of brain tumor biomechanics and response to radiation treatment", J. Biomechanics, 49(9): 1524-1531, 2016.
    15.   T. Stylianopoulos, "Intelligent drug delivery systems for the treatment of solid tumors", European Journal of Nanomedicine, 8(1), 9-16, 2016.
    16.   Achilleos M., F. Mpekris, T. Stylianopoulos, and T. Krasia-Christoforou. "Structurally-defined semi-interpenetrating amphiphilic polymer networks with tunable and predictable mechanical response". RSC Advances 6(49): 43278-43283, 2016.
    17.   A. Stylianou and T. Stylianopoulos*, Atomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Components, BioNanoScience, 6(1), 33-46, 2016.
    18.   V. Gkretsi, A. Stylianou, P. Papageorgis, C. Polydorou, T. Stylianopoulos*, "Remodelling components of the tumor microenvironment enhances cancer therapy", Frontiers in Oncology, Vol. 5, article 214, 2015, doi: 10.3389/fonc.2015.00214.
    19.   E. J. Kepola, E. Loizou, C. S. Patrickios, E. Leontidis,C. Voutouri, T. Stylianopoulos, R. Schweins, M. Gradzielski,C. Krumm, J. C. Tiller, M. Kushnir, C. Wesdemiotis, Amphiphilic End-linked Conetworks Based on “Amphiphilic Polymer Conetworks Based on End-linked “Core-first” Star Block Copolymers: Structure Formation with Long-range Order, ACS Macro Letters, 4, 1163-1168, 2015.
    20.   P. A. Wijeratne, V. Vavourakis, J. H. Hipwell, C. Voutouri, P. Papageorgis, T. Stylianopoulos, A. Evans, D. J. Hawkes, "Multiscale modelling of solid tumour growth: the effect of collagen micromechanics", Biomechanics and Modeling in Mechanobiology,  15(5): 1079-1090, 2015.
    21.   Duda D.G., R.S. Heist, D.V. Sahani, T. Stylianopoulos, J.A. Engelman, and R.K. Jain. Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients. PNAS,  112(27): E3454, 2015.
    22.   I. Savva, E. Evagelou, G. Papaparaskeva, T. Leontiou, T. Stylianopoulos, K. Stylianou, T. Krasia-Cristoforou, "Alignment of Electrospun Polymer Fibers Using a Concave Target", RSC Advances, 5, 104400-104407, 2015.  
    23.   T. Stylianopoulos* and R. K. Jain, "Design considerations for nanotherapeutics in oncology", Nanomedicine: Nanotechnology, Biology and Medicine, 11(8), 1893-1907, 2015.  
    24.   P. Papaphilippou, I. Vyrides, F. Mpekris, T. Stylianopoulos, C. Papatrifonos, C. Theocharis, T. Krasia-Cristoforou, "Evaluation of novel, cationic, electrospun microfibrous membranes as absorbents in bacterial removal", RSC Advances, 5(83), 67617-67629, 2015.  
    25.   A. Pirentis, C. Polydorou, C. Voutouri, F. Mpekris, P. Papageorgis, T. Stylianopoulos*, "Remodelling of extracellular matrix due to solid stress accumulation during tumor growth", Connective Tissue Research,  56(5), 345-354, 2015. 
    26.   T. Stylianopoulos*, E.A. Economides, J. W. Baish, D. Fukumura, R. K. Jain, "Towards optimal design of cancer nanomedicines: Multistage nanoparticles for the treatment of solid tumors",  Annals of Biomedical Engineering, 43(9), 2291-2300, 2015.
    27.   F. Mpekris, S. Angeli, A. P. Pirentis, T. Stylianopoulos*, Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation and drug delivery, Biomechanics and Modeling in Mechanobiology, 14(6):1391-402, 2015. 
    28.   F. Mpekris, M. Achileos, E. Vasile, E. Vasile, T. Krasia-Christoforou, T. Stylianopoulos*, "Mechanical properties of structurally-defined magnetoactive polymer (co)networks", RSC Advances, 5(26): 20011-20019, 2015. 
    29.   P. Papageorgis and T. Stylianopoulos*, "The role of TGF-β in modulating the tumor microenvironmnet and drug delivery", International Journal of Oncology, 46: 933-943, 2015.
    30.   C. Voutouri and T. Stylianopoulos*, "Evolution of osmotic pressure in solid tumors", J. Biomechanics, 47(14), pp. 3441-3447, 2014.
    31.   C. Voutouri, F. Mpekris, P. Papageorgis, A. D. Odysseos, T. Stylianopoulos*, "The role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors," PLoSOne, 9(8):e104717, 2014.
    32.   R. K. Jain, J. D. Martin and T. Stylianopoulos*, "The role of mechanical forces in tumor progression and therapy", Annual Reviews of Biomedical Engineering, 16:321-46, 2014.
    33.   A. Achilleos, C. Loizidis, M. Hadjiandreou, T. Stylianopoulos, G. Mitsis, "Multiprocessing linear dynamics modeling for personalized tumor growth prediction", Annals of Biomedical Engineering, 42(5), pp. 1095-1111, 2014.
    34.   T. Stylianopoulos* and R.K. Jain, "Combining two strategies to improve perfusion and drug delivery in solid tumors", PNAS, 110 (46) 18632-18637, 2013. This article was commented by Nature Reviews Clinical Oncology.
    35.   Huang Y., T. Stylianopoulos, D. Duda, D. Fukumura and R. K. Jain, "Benefits of vascular normalization are dose and time dependent", Cancer Research, 73:7144-7146, 2013.
    36.   V. P. Chauhan, J.D. Martin, H. Liu, D. A. Lacorre, S. R. Jain, S. V. Kozin, T. Stylianopoulos, A. S. Mousa, X. Han, P. Adstamongkonkul, Z. Popovic, P. Huang, M. G. Bawendi, Y. Boucher, R. K. Jain, "Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumor blood vessels", Nature Communications, 4:2516,10.1038/ncomms.3516, 2013.
    37.   T. Stylianopoulos*, J. D. Martin, M. Snuderl, F. Mpekris, S. Jain and R. K. Jain, "Coevolution of solid stress and interstitial fluid pressure in tumor during progression: Implications for vascular collapse", Cancer Research, 73(13), pp. 3833-3841, 2013.
    38.   T. Stylianopoulos*, K. Soteriou, D. Fukumura and R. K. Jain. Cationic nanoparticles have superior transvascular flux in solid tumors: Insights from a mathematical model. Annals of Biomedical Engineering, 41(1), pp. 68-77, 2013. On the cover of Ann. Biomed. Eng.
    39.   T. Stylianopoulos*, M. Kokonou, S. Michael, A. Tryfonos, C. Rebholz, A.D. Odysseos, D. Doumanidis. "Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes", J. Biomedical Materials Research-Part B, 100Β(8), pp. 2222-2230, 2012.
    40.   T. Stylianopoulos, J. D. Martin, V. P. Chauhan, Saloni R. Jain, B. Diop-Frimpong, B. Smith, C. R. Ferrone, F. Hornicek, Y. Boucher L. L. Munn, and R. K. Jain. " Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors", PNAS, 109(38), pp. 15101-15108, 2012.This article was highlighted by PNAS and recommended by the Faculty of 1000.
    41.   V. P. Chauhan1, T. Stylianopoulos1, J. D. Martin, Z. Popovic, W. S. Kamoun, M. G. Bawendi, D. Fukumura, and R. K. Jain, "Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner", Nature Nanotechnology, 7, pp. 383-388, 2012. 1Equal contribution. A commentary in Nature Nanotechnology was written to accompany publication of this paper. This paper was highlighted by Nanomedicine Journal and recommended by the Faculty of 1000.
    42.   T. Stylianopoulos*, C. Wong, M. G. Bawendi, R. K. Jain, and D. Fukumura, " Multistage nanoparticles for improved delivery into tumor tissue", Methods in Enzymology, 508, pp. 109-130, 2012.
    43.   V. P. Chauhan, T. Stylianopoulos, Y. Boucher, and R. K. Jain, "Delivering of Molecular and Nanomedicine to Tumors: Transport Barriers and Strategies", Annual Reviews of Chemical and Biomolecular Engineering, Vol. 2, pp. 281-298, 2011.
    44.    C. R. Wong, T. Stylianopoulos, J. Cui, J. Martin, V. P. Chauhan, W. Jiang, Z. Popovic, R. K. Jain, M. G. Bawendi and D. Fukumura, "Multistage nanoparticle delivery system for deep penetration into tumor tissue", PNAS, 108(6), pp. 2426-2431, 2011. This paper was highlighted by PNAS and selected by Faculty of 1000 among the top 2% published articles in biology and medicine.
    45.   J. W. Baish, T. Stylianopoulos, R. M. Lanning, W. Kamoun, L. L. Munn, D. Fukumura, R. K. Jain, “Scaling rules for diffusive drug delivery in tumor and normal tissues”, PNAS, 108(5), pp. 1799-1803, 2011.This paper was highlighted by Nature Materials and selected by Faculty of 1000 among the top 2% published articles in biology and medicine.
    46.   T. Stylianopoulos, B. Diop-Frimpong, L. L. Munn, and R. K. Jain, "Diffusion Anisotropy in Collagen Gels and Tumors: The Effect of Fiber Network Orientation", Biophysical J., 99, pp. 3119-3128, 2010.
    47.   R. K. Jain and T. Stylianopoulos, "Delivering Nanomedicine to Solid Tumors", Nature Reviews Clinical Oncology, 7, pp. 653-664, 2010.
    48.   T. Stylianopoulos, M. Z. Poh, N. Insin, L. L. Munn, D. Fukumura, M. Bawendi, R. K. Jain, “Diffusion of Particles in the Extracellular Matrix: Effect of Repulsive Electrostatic Interactions”, Biophysical J., 99(5), pp. 1342-1349, 2010.
    49.   V. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, “Three-dimensional Microscopy of the Tumor Microenvironment in vivo Using Optical Frequency Domain Imaging,” Nature Medicine, 15(10), pp. 1219-1223, 2009. This paper was on the cover of Nature Medicine and highlighted by Nature.
    50.   W. Mok, T. Stylianopoulos, Y. Boucher, R. K. Jain, “Mathematical Modeling of Herpes Simplex Virus Distribution in Solid Tumors: Implications for Cancer Gene Therapy,” Clinical Cancer Research, 15(7), pp. 2352-2360, 2009.
    51.   E. A. Sander, T. Stylianopoulos, R. T. Tranquillo, and V. H. Barocas, “Image-based Multi-scale Modeling Predicts Tissue-level and Network-level Fiber Reorganization in Stretched Cell-compacted Collagen Gels”, PNAS, 106(42), pp. 17675-17680, 2009.
    52.   E. A. Sander, T. Stylianopoulos, R. T. Tranquillo, and V. H. Barocas, “The Mechanics of Collagen Fiber Networks in Bioartificial Tissues: Multiscale Models Compared to Quantitative Polarized Light Microscopy”, IEEE Engineering in Medicine and Biology, 28(3), pp. 10-18, 2009.
    53.   X. Luo, T. Stylianopoulos,V. H. Barocas, and M. S. Shephard, "Multiscale Computation for Soft Tissues with Complex Geometries", Journal of Engineering with Computers, 25 (1), pp. 87-95, 2009.
    54.   T. Stylianopoulos, A. Yeckel, J. J. Derby, X. Luo, M. S. Shephard, E. A. Sander, and V. H. Barocas, “Permeability Calculations in Three-dimensional Isotropic and Oriented Fiber Networks,” J. Phys. Fluids, 20, 123601, 2008.
    55.   T. Stylianopoulos,C. A. Bashur, A. S. Goldstein, S. A. Guelcher, and V. H. Barocas, "Computational Predictions of the Tensile Properties of Electrospun Fiber Meshes: Effect of Fiber Diameter and Fiber Orientation", Journal of the Mechanical Behavior of Biomedical Materials, 1(4), pp. 326-335, 2008.
    56.   P. L. Chandran, T. Stylianopoulos,and V. H. Barocas, “Microstructure Based, Multiscale Modeling for the Mechanical Behavior of Hydrated Fiber Networks”, SIAM J. Multiscale Modeling and Simulation, 7 (1), pp. 22-43, 2008.
    57.   T. Stylianopoulos, A. Aksan, and V. H. Barocas, “A Structure-Based, Kinetic Model of Soft Tissue Thermomechanics," Biophys. J., 94, pp. 717-725, 2008.
    58.   T. Stylianopoulos, and V. H. Barocas, “Multiscale, Structure-based Modeling for the Elastic Mechanical Behavior of Arterial Walls”, J. Biomech. Eng., 129, pp. 611-618, 2007.
    59.   T. Stylianopoulos, and V. H. Barocas, “Volume Averaging Theory for the Study of the Mechanics of Collagen Networks”, Comput. Meth. Appl. Mech. Engrg., 196, pp. 2981-2990, 2007.
    60.   M. L. Oyen, R.F. Cook, T. Stylianopoulos, V.H Barocas, S.E. Calvin, and D.V. Landers, “Uniaxial and Biaxial Mechanical Behavior of Human Amnion”, J. of Mater. Res. 20 (11), pp. 2902-09, 2005.

    Profile Information

    Diploma in Chemical Engineering, 2003
    National Technical University of Athens, Greece
     
    PhD in Chemical Engineering, 2008
    University of Minnesota, USA
     
    Postdoctoral training, Department of Radiation Oncology
    Massachusetts General Hospital / Harvard Medical School, USA
     
    Triantafyllos received a Diploma in Chemical Engineering from National Technical University of Athens, Greece (GPA: 9.34/10) in 2003. The same year he joined the Chemical Engineering graduate program at the University of Minnesota, USA to pursue his doctoral studies. He worked with Professor Victor Barocas on modeling the mechanical response of native and bioartificial tissues. During his doctoral studies, he was elected twice top doctoral student of the department. After the completion of his PhD., in May 2008, Triantafyllos worked as a postdoctoral fellow in Dr. Rakesh Jain's lab in the department of Radiation Oncology at Harvard Medical School and Massachusetts General Hospital, USA. In Dr. Jain's lab he performed research in a mixture of experimental and computational problems for optimizing the delivery of nanomedicine to solid tumors. In September 2010, he joined the faculty of the Mechanical and Manufacturing Engineering department at the University of Cyprus.
     

    Triantafyllos has co-authored over 90 publications published or accepted for publication in peer-review journals. His publication record includes four articles in Nature journals (Nature Nanotechnology, Nature Medicine, Nature Communications and Nature Reviews Clinical Oncology), seven in PNAS, and two in Cancer Research. h-index:29, > 5000 hetero-citations (Web-of-Science) | h-index:32, > 7500 citations (GoogleScholar).

    He has received a highly selective research grant by the European Research Council in 2013 as well as the prestigious Y. C. Fung Young Investigator award by the American Society of Mechanical Engineers in 2016 (https://www.asme.org/about-asme/participate/honors-awards/achievement-awards/y-c-fung-young-investigator-award). Triantafyllos was also the recipient of the 2014 Most Cited Paper Award by the Biomedical Enigneering Society (BMES) of the USA in 2014 and the New Researcher Award by the Research Promotion Foundation of Cyprus the same year.  
     
    Triantafyllos is a member of the American Society of Mechanical Engineers, the Biomedical Engineering Society of the USA, the European Foundation of Clinical Nanomedicine, the European Society of Biomechanics and the Greek Association of Computational Mechanics.
    The major focus of the current research is on the mechanics (solid and fluid) and drug delivery of solid tumors. I study the evolution of fluid and solid stresses in tumors and how these stresses correlate to tumors' patho-physiology. Furthermore, I investigate strategies to improve delivery of chemo- and nano-therapeutics to tumors by either modifying the tumor microenvironment or developing rules for the optimal design of therapeutic agents. Areas of interest include 1) development of therapeutic strategies to re-engineer solid tumors in order to improve therapy; 2) mathematical modeling of the fluid and solid mechanics of cancer; 3) investigation of specific genes that are related to cancer metastasis in relation to tumor stiffness; and 4) response of stromal cells to mechanical stimuli.
     
     Current Funding ID:
     
    European Research Council (ERC) Starting Grant (ERC-2013-StG-336839 ReEngineeringCancer). Title: 'Re-engineering the tumor microenvironment to alleviate mechanical stresses and improve chemotherapy'. 1,440,360 Euros. January 2014 - December 2019.
     
    Marie-Curie International Reintegration Grant (PIRG08-GA-2010-276894 Cancer Nanomedicine). Grant Title: 'Optimizing the Delivery of Nanomedicine to Solid Tumors'. 100,000 Euros. August 2011- July 2015 (http://www.eng.ucy.ac.cy/cancernano/).
     
    Horizon 2020, Marie Skłodowska-Curie Individual Fellowship, (MSCA-IF-2014-657139 STROMAMECH). Grant Title: "Targeting stromal cells to modify tumor mechanical microenvironment and optimize drug delivery".  €151,649. May 2015 - April 2017.

    Horizon 2020, Marie Skłodowska-Curie Individual Fellowship, (MSCA-IF-2014-658769-MYO-DESMOPLASIA). Grant Title: "Modulating the behaviour of cancer myofibroblasts to control tumour desmoplasia".  €163,649. June 2015 - May 2017.

    Young Investigator Award, Research Promotion Foundation of Cyprus, €35,000. June 2015 - October 2016.

    For a detailed list please visit our website at www.ucy.ac.cy/cancer_biophysics/en/publications
    1.       V. Gkretsi, A. Stylianou, T. Stylianopoulos*, Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, b-catenin and urokinase-plasminogen activator (uPA), Experimental Cell Research, accepted, 2016.
    2.       V. Gkretsi, A. Stylianou, M. Louca, T. Stylianopoulos*, "Identification of Ras Suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach", Oncotarget, conditionally accepted, 2017.
    3.       C. Polydorou, F. Mpekris, P. Papageorgis, V. Voutouri, T. Stylianopoulos*, "Pirfenidone normalizes the tumor microenvironment to improve chemotherapy", Oncotarget, accepted, 2017.
    4.       S. Angeli, T. Stylianopoulos*, "Experimental measurements and mathematical modeling towards quantification of brain swelling stress", J. Biomechanics, accepted, 2017.
    5.       P. Papageorgis, C. Polydorou, F. Mpekris, C. Voutouri, E. Agathokleous, C. Kapnissi-Christodoulou, T. Stylianopoulos*, "Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nano-therapeutics in a size-dependent manner", Scientific Reports, accepted, 2017.
    6.       F. Mpekris, J.W. Baish, T. Stylianopoulos*, R. K. Jain, "Role of vascular normalization in benefit from metronomic chemotherapy: Insights from a mathematical model", PNAS, accepted, 2017.
    7.       A. Stylianou, V. Gkretsi, C. S. Patrickios, T. Stylianopoulos*, "Exploring the nano-surface of collagenous and other fibrotic tissues with AFM", Methods in Enzymology, accepted, 2016.
    8.       V. Vavourakis, P.A. Wijeratne, R. Shipley, M. Loizidou, T. Stylianopoulos, D. J. Hawkes, "A validated multiscale in-silico model for mechano-sensitive tumour angiogenesis and growth", PLoS Computational Biology, accepted, 2016.
    9.       C. Voutouri, C. Polydorou, P. Papageorgis, V. Gkretsi and T. Stylianopoulos*, "Hyaluronan-derived swelling of solid tumors, the contribution of collagen and cancer cells and implications for cancer therapy", Neoplasia, 18(12):732-741, 2016.
    10.   J.C.L. Alfonso, A. Köhn-Luque, T. Stylianopoulos, F. Feuerhake, A. Deutch, H. Hatzikirou. " Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights", Scientific Reports, 6:37283, 2016.
    11.   T. Stylianopoulos*. "The solid mechanics of cancer and strategies for improved therapy". Journal of Biomechanical Engineering (In Press), 2016.
    12.   D. Ambrosi, S. Pezzuto, D. Riccobelli, T. Stylianopoulos, C. Ciarletta, "Solid tumors are poroelastic solids with a chemo-mechanical feedback on growth", J. Elasticity, accepted, 2016.
    13.   Kitiri E., C. Patrickios, C. Voutouri, T. Stylianopoulos, I. Hoffmann, R. Schweins, and M. Gradzielski. "Synthesis and characterization of double-networks based on pH-responsive, amphiphilic "core-first" star first polymer conetworks prepared by sequential RAFT polymerization". Polymer Chemistry 8 (1), 245-259, 2016.
    14.   S. Aggeli and T. Stylianopoulos*,"Biphasic modeling of brain tumor biomechanics and response to radiation treatment", J. Biomechanics, 49(9): 1524-1531, 2016.
    15.   T. Stylianopoulos, "Intelligent drug delivery systems for the treatment of solid tumors", European Journal of Nanomedicine, 8(1), 9-16, 2016.
    16.   Achilleos M., F. Mpekris, T. Stylianopoulos, and T. Krasia-Christoforou. "Structurally-defined semi-interpenetrating amphiphilic polymer networks with tunable and predictable mechanical response". RSC Advances 6(49): 43278-43283, 2016.
    17.   A. Stylianou and T. Stylianopoulos*, Atomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Components, BioNanoScience, 6(1), 33-46, 2016.
    18.   V. Gkretsi, A. Stylianou, P. Papageorgis, C. Polydorou, T. Stylianopoulos*, "Remodelling components of the tumor microenvironment enhances cancer therapy", Frontiers in Oncology, Vol. 5, article 214, 2015, doi: 10.3389/fonc.2015.00214.
    19.   E. J. Kepola, E. Loizou, C. S. Patrickios, E. Leontidis,C. Voutouri, T. Stylianopoulos, R. Schweins, M. Gradzielski,C. Krumm, J. C. Tiller, M. Kushnir, C. Wesdemiotis, Amphiphilic End-linked Conetworks Based on “Amphiphilic Polymer Conetworks Based on End-linked “Core-first” Star Block Copolymers: Structure Formation with Long-range Order, ACS Macro Letters, 4, 1163-1168, 2015.
    20.   P. A. Wijeratne, V. Vavourakis, J. H. Hipwell, C. Voutouri, P. Papageorgis, T. Stylianopoulos, A. Evans, D. J. Hawkes, "Multiscale modelling of solid tumour growth: the effect of collagen micromechanics", Biomechanics and Modeling in Mechanobiology,  15(5): 1079-1090, 2015.
    21.   Duda D.G., R.S. Heist, D.V. Sahani, T. Stylianopoulos, J.A. Engelman, and R.K. Jain. Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients. PNAS,  112(27): E3454, 2015.
    22.   I. Savva, E. Evagelou, G. Papaparaskeva, T. Leontiou, T. Stylianopoulos, K. Stylianou, T. Krasia-Cristoforou, "Alignment of Electrospun Polymer Fibers Using a Concave Target", RSC Advances, 5, 104400-104407, 2015.  
    23.   T. Stylianopoulos* and R. K. Jain, "Design considerations for nanotherapeutics in oncology", Nanomedicine: Nanotechnology, Biology and Medicine, 11(8), 1893-1907, 2015.  
    24.   P. Papaphilippou, I. Vyrides, F. Mpekris, T. Stylianopoulos, C. Papatrifonos, C. Theocharis, T. Krasia-Cristoforou, "Evaluation of novel, cationic, electrospun microfibrous membranes as absorbents in bacterial removal", RSC Advances, 5(83), 67617-67629, 2015.  
    25.   A. Pirentis, C. Polydorou, C. Voutouri, F. Mpekris, P. Papageorgis, T. Stylianopoulos*, "Remodelling of extracellular matrix due to solid stress accumulation during tumor growth", Connective Tissue Research,  56(5), 345-354, 2015. 
    26.   T. Stylianopoulos*, E.A. Economides, J. W. Baish, D. Fukumura, R. K. Jain, "Towards optimal design of cancer nanomedicines: Multistage nanoparticles for the treatment of solid tumors",  Annals of Biomedical Engineering, 43(9), 2291-2300, 2015.
    27.   F. Mpekris, S. Angeli, A. P. Pirentis, T. Stylianopoulos*, Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation and drug delivery, Biomechanics and Modeling in Mechanobiology, 14(6):1391-402, 2015. 
    28.   F. Mpekris, M. Achileos, E. Vasile, E. Vasile, T. Krasia-Christoforou, T. Stylianopoulos*, "Mechanical properties of structurally-defined magnetoactive polymer (co)networks", RSC Advances, 5(26): 20011-20019, 2015. 
    29.   P. Papageorgis and T. Stylianopoulos*, "The role of TGF-β in modulating the tumor microenvironmnet and drug delivery", International Journal of Oncology, 46: 933-943, 2015.
    30.   C. Voutouri and T. Stylianopoulos*, "Evolution of osmotic pressure in solid tumors", J. Biomechanics, 47(14), pp. 3441-3447, 2014.
    31.   C. Voutouri, F. Mpekris, P. Papageorgis, A. D. Odysseos, T. Stylianopoulos*, "The role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors," PLoSOne, 9(8):e104717, 2014.
    32.   R. K. Jain, J. D. Martin and T. Stylianopoulos*, "The role of mechanical forces in tumor progression and therapy", Annual Reviews of Biomedical Engineering, 16:321-46, 2014.
    33.   A. Achilleos, C. Loizidis, M. Hadjiandreou, T. Stylianopoulos, G. Mitsis, "Multiprocessing linear dynamics modeling for personalized tumor growth prediction", Annals of Biomedical Engineering, 42(5), pp. 1095-1111, 2014.
    34.   T. Stylianopoulos* and R.K. Jain, "Combining two strategies to improve perfusion and drug delivery in solid tumors", PNAS, 110 (46) 18632-18637, 2013. This article was commented by Nature Reviews Clinical Oncology.
    35.   Huang Y., T. Stylianopoulos, D. Duda, D. Fukumura and R. K. Jain, "Benefits of vascular normalization are dose and time dependent", Cancer Research, 73:7144-7146, 2013.
    36.   V. P. Chauhan, J.D. Martin, H. Liu, D. A. Lacorre, S. R. Jain, S. V. Kozin, T. Stylianopoulos, A. S. Mousa, X. Han, P. Adstamongkonkul, Z. Popovic, P. Huang, M. G. Bawendi, Y. Boucher, R. K. Jain, "Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumor blood vessels", Nature Communications, 4:2516,10.1038/ncomms.3516, 2013.
    37.   T. Stylianopoulos*, J. D. Martin, M. Snuderl, F. Mpekris, S. Jain and R. K. Jain, "Coevolution of solid stress and interstitial fluid pressure in tumor during progression: Implications for vascular collapse", Cancer Research, 73(13), pp. 3833-3841, 2013.
    38.   T. Stylianopoulos*, K. Soteriou, D. Fukumura and R. K. Jain. Cationic nanoparticles have superior transvascular flux in solid tumors: Insights from a mathematical model. Annals of Biomedical Engineering, 41(1), pp. 68-77, 2013. On the cover of Ann. Biomed. Eng.
    39.   T. Stylianopoulos*, M. Kokonou, S. Michael, A. Tryfonos, C. Rebholz, A.D. Odysseos, D. Doumanidis. "Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes", J. Biomedical Materials Research-Part B, 100Β(8), pp. 2222-2230, 2012.
    40.   T. Stylianopoulos, J. D. Martin, V. P. Chauhan, Saloni R. Jain, B. Diop-Frimpong, B. Smith, C. R. Ferrone, F. Hornicek, Y. Boucher L. L. Munn, and R. K. Jain. " Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors", PNAS, 109(38), pp. 15101-15108, 2012.This article was highlighted by PNAS and recommended by the Faculty of 1000.
    41.   V. P. Chauhan1, T. Stylianopoulos1, J. D. Martin, Z. Popovic, W. S. Kamoun, M. G. Bawendi, D. Fukumura, and R. K. Jain, "Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner", Nature Nanotechnology, 7, pp. 383-388, 2012. 1Equal contribution. A commentary in Nature Nanotechnology was written to accompany publication of this paper. This paper was highlighted by Nanomedicine Journal and recommended by the Faculty of 1000.
    42.   T. Stylianopoulos*, C. Wong, M. G. Bawendi, R. K. Jain, and D. Fukumura, " Multistage nanoparticles for improved delivery into tumor tissue", Methods in Enzymology, 508, pp. 109-130, 2012.
    43.   V. P. Chauhan, T. Stylianopoulos, Y. Boucher, and R. K. Jain, "Delivering of Molecular and Nanomedicine to Tumors: Transport Barriers and Strategies", Annual Reviews of Chemical and Biomolecular Engineering, Vol. 2, pp. 281-298, 2011.
    44.    C. R. Wong, T. Stylianopoulos, J. Cui, J. Martin, V. P. Chauhan, W. Jiang, Z. Popovic, R. K. Jain, M. G. Bawendi and D. Fukumura, "Multistage nanoparticle delivery system for deep penetration into tumor tissue", PNAS, 108(6), pp. 2426-2431, 2011. This paper was highlighted by PNAS and selected by Faculty of 1000 among the top 2% published articles in biology and medicine.
    45.   J. W. Baish, T. Stylianopoulos, R. M. Lanning, W. Kamoun, L. L. Munn, D. Fukumura, R. K. Jain, “Scaling rules for diffusive drug delivery in tumor and normal tissues”, PNAS, 108(5), pp. 1799-1803, 2011.This paper was highlighted by Nature Materials and selected by Faculty of 1000 among the top 2% published articles in biology and medicine.
    46.   T. Stylianopoulos, B. Diop-Frimpong, L. L. Munn, and R. K. Jain, "Diffusion Anisotropy in Collagen Gels and Tumors: The Effect of Fiber Network Orientation", Biophysical J., 99, pp. 3119-3128, 2010.
    47.   R. K. Jain and T. Stylianopoulos, "Delivering Nanomedicine to Solid Tumors", Nature Reviews Clinical Oncology, 7, pp. 653-664, 2010.
    48.   T. Stylianopoulos, M. Z. Poh, N. Insin, L. L. Munn, D. Fukumura, M. Bawendi, R. K. Jain, “Diffusion of Particles in the Extracellular Matrix: Effect of Repulsive Electrostatic Interactions”, Biophysical J., 99(5), pp. 1342-1349, 2010.
    49.   V. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, “Three-dimensional Microscopy of the Tumor Microenvironment in vivo Using Optical Frequency Domain Imaging,” Nature Medicine, 15(10), pp. 1219-1223, 2009. This paper was on the cover of Nature Medicine and highlighted by Nature.
    50.   W. Mok, T. Stylianopoulos, Y. Boucher, R. K. Jain, “Mathematical Modeling of Herpes Simplex Virus Distribution in Solid Tumors: Implications for Cancer Gene Therapy,” Clinical Cancer Research, 15(7), pp. 2352-2360, 2009.
    51.   E. A. Sander, T. Stylianopoulos, R. T. Tranquillo, and V. H. Barocas, “Image-based Multi-scale Modeling Predicts Tissue-level and Network-level Fiber Reorganization in Stretched Cell-compacted Collagen Gels”, PNAS, 106(42), pp. 17675-17680, 2009.
    52.   E. A. Sander, T. Stylianopoulos, R. T. Tranquillo, and V. H. Barocas, “The Mechanics of Collagen Fiber Networks in Bioartificial Tissues: Multiscale Models Compared to Quantitative Polarized Light Microscopy”, IEEE Engineering in Medicine and Biology, 28(3), pp. 10-18, 2009.
    53.   X. Luo, T. Stylianopoulos,V. H. Barocas, and M. S. Shephard, "Multiscale Computation for Soft Tissues with Complex Geometries", Journal of Engineering with Computers, 25 (1), pp. 87-95, 2009.
    54.   T. Stylianopoulos, A. Yeckel, J. J. Derby, X. Luo, M. S. Shephard, E. A. Sander, and V. H. Barocas, “Permeability Calculations in Three-dimensional Isotropic and Oriented Fiber Networks,” J. Phys. Fluids, 20, 123601, 2008.
    55.   T. Stylianopoulos,C. A. Bashur, A. S. Goldstein, S. A. Guelcher, and V. H. Barocas, "Computational Predictions of the Tensile Properties of Electrospun Fiber Meshes: Effect of Fiber Diameter and Fiber Orientation", Journal of the Mechanical Behavior of Biomedical Materials, 1(4), pp. 326-335, 2008.
    56.   P. L. Chandran, T. Stylianopoulos,and V. H. Barocas, “Microstructure Based, Multiscale Modeling for the Mechanical Behavior of Hydrated Fiber Networks”, SIAM J. Multiscale Modeling and Simulation, 7 (1), pp. 22-43, 2008.
    57.   T. Stylianopoulos, A. Aksan, and V. H. Barocas, “A Structure-Based, Kinetic Model of Soft Tissue Thermomechanics," Biophys. J., 94, pp. 717-725, 2008.
    58.   T. Stylianopoulos, and V. H. Barocas, “Multiscale, Structure-based Modeling for the Elastic Mechanical Behavior of Arterial Walls”, J. Biomech. Eng., 129, pp. 611-618, 2007.
    59.   T. Stylianopoulos, and V. H. Barocas, “Volume Averaging Theory for the Study of the Mechanics of Collagen Networks”, Comput. Meth. Appl. Mech. Engrg., 196, pp. 2981-2990, 2007.
    60.   M. L. Oyen, R.F. Cook, T. Stylianopoulos, V.H Barocas, S.E. Calvin, and D.V. Landers, “Uniaxial and Biaxial Mechanical Behavior of Human Amnion”, J. of Mater. Res. 20 (11), pp. 2902-09, 2005.
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