ΓΙΩΡΓΟΣ ΑΠΙΔΙΑΝΑΚΗΣ
ΑΠΙΔΙΑΝΑΚΗΣ ΓΙΩΡΓΟΣ
APIDIANAKIS YIORGOS
...
ASSOCIATE PROFESSOR
Department of Biological Sciences
FST 01 - Faculty of Pure and Applied Sciences
University Campus
FST01, 107
+357-22893767
+357-22892881
CIHS.cs.ucy.ac.cy

Προσωπικό Προφίλ

- education
B.S. 1994 Biology, University of Crete, Greece
M.S. 1996 Molecular Genetics, University of Crete, Greece
Ph.D. 2001 Molecular Genetics, University of Crete, Greece
 
- academic positions
2020-     Associate Professor, Department of Biological Sciences, University of Cyprus
2012-19 Assistant Professor, Department of Biological Sciences, University of Cyprus
2008-12 Instructor, Harvard Medical School, Boston, USA
2008-12 Assistant in Biology, Massachusetts General Hospital, USA
2008-12 Research Staff, Shriners Hospital for Children, Boston,USA
2002-08 Postdoctoral Fellow, Harvard Medical School, USA
 
 - web research profiles
 
 
 
Our goal is to establish synergisms among gene allelles, microbes and the intestinal environment that predispose for intestinal inflammation and cancer. The work of our team aims towards a deeper understanding of critical aspects of intestinal human disease, including inflammatory bowel disease and intestinal tumor formation and metastasis. We use Drosophila and human genetics, histopathology and quantitative population genetics analysis to identify the host genes, microbes and dietary factors that mediate inflammation and predispose for cancer. We model human diseases primarily in flies, subsequently in mice and we follow up with human studies based on the high degree of conservation between Drosophila and mammalian signalling pathways controlling intestinal inflammation and cancer.
 
Key Funding & Licensing
A personalized risk assessment tool for Colorectal Cancer prevention through 3-prime mRNA sequencing of normalappearing mucosa in the Cypriot population
Research Promotion Foundation (Nicosia, Cyprus)
2019/07 to 2022/06| Grant to the Cyprus Intestinal Health Study
Grant number: EXCELLENCE 1216/0523
 
Biomarker assessment using Fecal, Blood and Colon Biopsy samples for Colon Cancer prevention in Cyprus
National Bioethics Committee (Nicosia, Cyprus)
2019/06 | Licenced to YA and colleagues
Protocol number: EEBK/ΕΠ/2019/23
 
Biomarker assessment in Fecal, Blood and Colon Biopsy samples for improved diagnosis and prognosis of Colon Cancer in the Cypriot Population
National Bioethics Committee (Nicosia, Cyprus)
2016/07 to 2019/06 | Licenced to YA and colleagues
Protocol number: EEBK/ΕΠ/2015/38
 
Dietary and pharmacological intervention for preventing intestinal tumorigenesis
Fondation Sante (Athens, Greece)
2017/03 to 2019/02 | Grant to YA
Grant number: YA-Sante2
 
Bacterial interactions that establish a low inflammatory state in the Drosophila and mouse intestine
Fondation Sante (Athens, Greece)
2013/01 to 2014/12 | Grant to YA
Grant number: YA-Sante
 
Identifying host and microbial factors that promote intestinal inflammation and cancer using Drosophila
European Commission (Brussels, Belgium)
2012/05 to 2016/04 | Award to YA
Award number: Marie Curie CIG# 303586
 
Identification of Human Intestinal Bacteria that Promote or Inhibit Inflammation
U.S. Department of Defense (DC, DC, United States)
2011/08 to 2012/07 | Award to YA
Award number: PR100240

 
Current Lab Members
Myrofora Panagi (PhD Student)
Eleni Kamilari (PhD Student)
Savvas Telonis (PhD Student)
Maria Koumouri (PhD Student)
Christina Michail (MSc thesis)
Antri Demetriou (MSC thesis)
Gavriela Sianiou (MSc thesis)
Panagiota Gianni (MSc thesis)
 
 
 
Alumni
Popi Georgiades (Postdoctoral Researcher, 2016-2018)
Stavria Panagidou (PhD Student, 2012-2019)
Theodoulakis Christofi (PhD Student, 2012-2018)
Amalia Evangelou (BSc thesis, 2016; MSc thesis, 2018)
Sofia Kalanidou (BSc thesis, 2016; MSc 2018)
Androniki Giakoumi (BSc thesis, 2019)
Olympiada Georgiou (BSc thesis, 2019)
Gavriela Sianiou (BSc thesis, 2018)
Panagiota Gianni (BSC thesis, 2018)
Soteroulla Ellina (BSc thesis, 2017)
Rafaella Athanasiou (BSc thesis, 2017)
Irene Dieronitou (BSc thesis, 2014; MSc thesis, 2016)
Christina Michail (BSc thesis, 2016)
Stella Irakleus (BSc thesis, 2016)
Styliani Polydorou (BSc thesis, 2016)
Alexandros Patapiou (BSc thesis, 2015)
Maria Glykenou (BSc thesis, 2015)
Maria Michail (BSc thesis, 2015)
Kalodoti Avgousti (BSc thesis, 2014)
Stelios Theofilou (BSc thesis, 2014)
Maria Dimosthenous (BSc thesis, 2014)
Panayiota Markou (internship, 2013)
Eleni Ioannidou (BSc thesis, 2013)
Ilias Tzelepis (BSc thesis, 2013)
Stefania Kapsetaki (BSc thesis, 2013)

 
Teaching
Genetics BIO-201 (full semester mandatory course, 2013-present)
Immunology BIO-471 (full semester mandatory course, 2013-present)
Bacterial Pathogenesis BIO-372 (full semester elective course, 2014-2017)
Genes, Microbes & Intestinal Environment BIO-768 (full semester graduate course, 2018-present)
 
 
  1. Christofi, T., Panayidou, S., Dieronitou, I., Michael, C. and Apidianakis Y. Metabolic output defines Escherichia coli as a health-promoting microbe against intestinal Pseudomonas aeruginosa. Sci Rep 9, 14463 (2019)
  2. Evangelou A, Ignatiou A, Antoniou C, Kalanidou S, Chatzimatthaiou S, Shianiou G, Ellina S, Athanasiou R, Panagi M, Apidianakis Y, Pitsouli C. Unpredictable Effects of the Genetic Background of Transgenic Lines in Physiological Quantitative Traits. G3 (Bethesda). 2019 Nov 5;9(11):3877-3890.
  3. Panagi M, Georgila K, Eliopoulos AG, Apidianakis Y. Constructing personalized longitudinal holo'omes of colon cancer-prone humans and their modeling in flies and mice. Oncotarget. 2019 Jun 25; 10(41): 4224–4246.
  4. Apidianakis Y, Tamamouna V, Teloni S and Pitsouli P. Intestinal Stem Cells: a decade of intensive research in Drosophila and the road ahead. Elsevier 2017 Advances in Insect Physiology Volume 52: Insect Immunity – Chapter Five. pp139–178
  5. Apidianakis Y, Eliopoulos AG. A holo'ome approach in colon cancer: we change as we age. EMBO Rep. 2015 Oct;16(10):1239-40. doi: 10.15252/embr.201541224.
  6. Kapsetaki, S-E., Tzelepis I, Avgousti K, Ioannis Livadaras, Garantonakis N, Varikou K & Apidianakis Y.The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies. Nat. Commun. (2014) 5:4401 doi: 10.1038/ncomms5401.
  7. Panayidou S, Ioannidou E & Apidianakis Y. Human pathogenic bacteria, fungi and viruses in Drosophila: disease modeling, lessons and shortcomings. Virulence 2014 Jan 7;5(2).
  8. Markou P & Apidianakis Y. Pathogenesis of Pseudomonas aeruginosa infection in patients with cancer. Front Cell Infect Microbiol. 2014 Jan 7;3:115.
  9. Tzelepis I, Kapsetaki SE, Panayidou S & Apidianakis Y. Drosophila melanogaster: a first step and a stepping-stone to anti-infectives. Curr Opin Pharmacol. 2013 Oct;13(5):763-8.
  10. Christofi T & Apidianakis Y. Drosophila and the Hallmarks of Cancer. Adv Biochem Eng Biotechnol. 2013 Apr 25. PMID: 23615878
  11. Christofi T & Apidianakis Y. (2013) Drosophila immune priming against Pseudomonas aeruginosa is short-lasting and depends on cellular and humoral immunity. F1000Research 2013, 2:76
  12. Panayidou S & Apidianakis Y. Regenerative Inflammation: Lessons from Drosophila Intestinal Epithelium in Health and Disease. Pathogens. 2013; 2(2):209-231.
  13. Christofi T & Apidianakis Y. Ras-oncogenic Drosophila hindgut but not midgut cells use an inflammation-like program to disseminate to distant sites. Gut Microbes 2013 Jan-Feb;4(1):54-9.
  14. Bangi E, Pitsouli C, Rahme L, Cagan R & Apidianakis Y. Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. EMBO Rep. 2012 Jun 1;13(6):569-76.
  15. Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P,. Hamblin MR,. Tompkins RG, Xiao W, & Rahme LG. Down-regulation of glutatione S-transferase alpha 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection. FASEB J. 2012 Feb;26(2):730-7.
  16. Apidianakis Y & Rahme L. Drosophila as a model for human intestinal infection and pathology. Dis Model Mech. 2011 Jan;4(1):21-30.
  17. Apidianakis Y, Pitsouli C, Perrimon N & Rahme LG. Synergy between Bacterial Infection and Genetic Predisposition in Intestinal Dysplasia. Proc Natl Acad Sci USA. 2009 Dec; 106(49):20883-8.
  18. Apidianakis Y & Rahme LG. Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection. Nature Protocols 2009 Aug 13; 4:1285-1294.
  19. Apidianakis Y, Mindrinos, MN Xiao W, Tegos GP, Papisov MI, Hamblin MR, Tompkins RG, Davis RW, and Rahme LG. Involvement of Skeletal Muscle Gene Regulatory Network in Susceptibility to Wound Infection following Trauma. PLoS ONE, 2007 Dec 26;2(12):e1356
  20. Apidianakis Y, Mindrinos MN, Xiao W, Lau GW, Baldini RL, Davis RW, Rahme LG. Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression. Proc Natl Acad Sci USA. 2005 Feb;102(7):2573-8.

Profile Information

- education
B.S. 1994 Biology, University of Crete, Greece
M.S. 1996 Molecular Genetics, University of Crete, Greece
Ph.D. 2001 Molecular Genetics, University of Crete, Greece
 
- academic positions
2020-     Associate Professor, Department of Biological Sciences, University of Cyprus
2012-19 Assistant Professor, Department of Biological Sciences, University of Cyprus
2008-12 Instructor, Harvard Medical School, Boston, USA
2008-12 Assistant in Biology, Massachusetts General Hospital, USA
2008-12 Research Staff, Shriners Hospital for Children, Boston,USA
2002-08 Postdoctoral Fellow, Harvard Medical School, USA
 

Modeling of human infectious diseases and carcinogenesis in Drosophila and mouse (click for more)

Our goal is to establish synergisms among gene allelles, microbes and the intestinal environment that predispose for intestinal inflammation and cancer. The work of our team aims towards a deeper understanding of critical aspects of intestinal human disease, including inflammatory bowel disease and intestinal tumor formation and metastasis. We use Drosophila and human genetics, histopathology and quantitative population genetics analysis to identify the host genes, microbes and dietary factors that mediate inflammation and predispose for cancer. We model human diseases primarily in flies, subsequently in mice and we follow up with human studies based on the high degree of conservation between Drosophila and mammalian signalling pathways controlling intestinal inflammation and cancer.

Key Funding & Licensing
A personalized risk assessment tool for Colorectal Cancer prevention through 3-prime mRNA sequencing of normalappearing mucosa in the Cypriot population
Research Promotion Foundation (Nicosia, Cyprus)
2019/07 to 2022/06| Grant to the Cyprus Intestinal Health Study
Grant number: EXCELLENCE 1216/0523
 
Biomarker assessment using Fecal, Blood and Colon Biopsy samples for Colon Cancer prevention in Cyprus
National Bioethics Committee (Nicosia, Cyprus)
2019/06 | Licenced to YA and colleagues
Protocol number: EEBK/ΕΠ/2019/23
 
Biomarker assessment in Fecal, Blood and Colon Biopsy samples for improved diagnosis and prognosis of Colon Cancer in the Cypriot Population
National Bioethics Committee (Nicosia, Cyprus)
2016/07 to 2019/06 | Licenced to YA and colleagues
Protocol number: EEBK/ΕΠ/2015/38
 
Dietary and pharmacological intervention for preventing intestinal tumorigenesis
Fondation Sante (Athens, Greece)
2017/03 to 2019/02 | Grant to YA
Grant number: YA-Sante2
 
Bacterial interactions that establish a low inflammatory state in the Drosophila and mouse intestine
Fondation Sante (Athens, Greece)
2013/01 to 2014/12 | Grant to YA
Grant number: YA-Sante
 
Identifying host and microbial factors that promote intestinal inflammation and cancer using Drosophila
European Commission (Brussels, Belgium)
2012/05 to 2016/04 | Award to YA
 
Award number: Marie Curie CIG# 303586
Identification of Human Intestinal Bacteria that Promote or Inhibit Inflammation
U.S. Department of Defense (DC, DC, United States)
2011/08 to 2012/07 | Award to YA
Award number: PR100240

 

Current Lab Members
Myrofora Panagi (PhD Student)
Eleni Kamilari (PhD Student)
Savvas Telonis (PhD Student)
Maria Koumouri (PhD Student)
Christina Michail (MSc thesis)
Antri Demetriou (MSC thesis)
Gavriela Sianiou (MSc thesis)
Panagiota Gianni (MSc thesis)
 
Alumni
Popi Georgiades (Postdoctoral Researcher, 2016-2018)
Stavria Panagidou (PhD Student, 2012-2019)
Theodoulakis Christofi (PhD Student, 2012-2018)
Amalia Evangelou (BSc thesis, 2016; MSc thesis, 2018)
Sofia Kalanidou (BSc thesis, 2016; MSc 2018)
Androniki Giakoumi (BSc thesis, 2019)
Olympiada Georgiou (BSc thesis, 2019)
Gavriela Sianiou (BSc thesis, 2018)
Panagiota Gianni (BSC thesis, 2018)
Soteroulla Ellina (BSc thesis, 2017)
Rafaella Athanasiou (BSc thesis, 2017)
Irene Dieronitou (BSc thesis, 2014; MSc thesis, 2016)
Christina Michail (BSc thesis, 2016)
Stella Irakleus (BSc thesis, 2016)
Styliani Polydorou (BSc thesis, 2016)
Alexandros Patapiou (BSc thesis, 2015)
Maria Glykenou (BSc thesis, 2015)
Maria Michail (BSc thesis, 2015)
Kalodoti Avgousti (BSc thesis, 2014)
Stelios Theofilou (BSc thesis, 2014)
Maria Dimosthenous (BSc thesis, 2014)
Panayiota Markou (internship, 2013)
Eleni Ioannidou (BSc thesis, 2013)
Ilias Tzelepis (BSc thesis, 2013)
Stefania Kapsetaki (BSc thesis, 2013)

 

Teaching
Genetics BIO-201 (full semester mandatory course, 2013-present)
Immunology BIO-471 (full semester mandatory course, 2013-present)
Bacterial Pathogenesis BIO-372 (full semester elective course, 2014-2017)
Genes, Microbes & Intestinal Environment BIO-768 (full semester graduate course, 2018-present)

  1. Christofi, T., Panayidou, S., Dieronitou, I., Michael, C. and Apidianakis Y. Metabolic output defines Escherichia coli as a health-promoting microbe against intestinal Pseudomonas aeruginosa. Sci Rep 9, 14463 (2019)
  2. Evangelou A, Ignatiou A, Antoniou C, Kalanidou S, Chatzimatthaiou S, Shianiou G, Ellina S, Athanasiou R, Panagi M, Apidianakis Y, Pitsouli C. Unpredictable Effects of the Genetic Background of Transgenic Lines in Physiological Quantitative Traits. G3 (Bethesda). 2019 Nov 5;9(11):3877-3890.
  3. Panagi M, Georgila K, Eliopoulos AG, Apidianakis Y. Constructing personalized longitudinal holo'omes of colon cancer-prone humans and their modeling in flies and mice. Oncotarget. 2019 Jun 25; 10(41): 4224–4246.
  4. Apidianakis Y, Tamamouna V, Teloni S and Pitsouli P. Intestinal Stem Cells: a decade of intensive research in Drosophila and the road ahead. Elsevier 2017 Advances in Insect Physiology Volume 52: Insect Immunity – Chapter Five. pp139–178
  5. Apidianakis Y, Eliopoulos AG. A holo'ome approach in colon cancer: we change as we age. EMBO Rep. 2015 Oct;16(10):1239-40. doi: 10.15252/embr.201541224.
  6. Kapsetaki, S-E., Tzelepis I, Avgousti K, Ioannis Livadaras, Garantonakis N, Varikou K & Apidianakis Y.The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies. Nat. Commun. (2014) 5:4401 doi: 10.1038/ncomms5401.
  7. Panayidou S, Ioannidou E & Apidianakis Y. Human pathogenic bacteria, fungi and viruses in Drosophila: disease modeling, lessons and shortcomings. Virulence 2014 Jan 7;5(2).
  8. Markou P & Apidianakis Y. Pathogenesis of Pseudomonas aeruginosa infection in patients with cancer. Front Cell Infect Microbiol. 2014 Jan 7;3:115.
  9. Tzelepis I, Kapsetaki SE, Panayidou S & Apidianakis Y. Drosophila melanogaster: a first step and a stepping-stone to anti-infectives. Curr Opin Pharmacol. 2013 Oct;13(5):763-8.
  10. Christofi T & Apidianakis Y. Drosophila and the Hallmarks of Cancer. Adv Biochem Eng Biotechnol. 2013 Apr 25. PMID: 23615878
  11. Christofi T & Apidianakis Y. (2013) Drosophila immune priming against Pseudomonas aeruginosa is short-lasting and depends on cellular and humoral immunity. F1000Research 2013, 2:76
  12. Panayidou S & Apidianakis Y. Regenerative Inflammation: Lessons from Drosophila Intestinal Epithelium in Health and Disease. Pathogens. 2013; 2(2):209-231.
  13. Christofi T & Apidianakis Y. Ras-oncogenic Drosophila hindgut but not midgut cells use an inflammation-like program to disseminate to distant sites. Gut Microbes 2013 Jan-Feb;4(1):54-9.
  14. Bangi E, Pitsouli C, Rahme L, Cagan R & Apidianakis Y. Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. EMBO Rep. 2012 Jun 1;13(6):569-76.
  15. Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P,. Hamblin MR,. Tompkins RG, Xiao W, & Rahme LG. Down-regulation of glutatione S-transferase alpha 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection. FASEB J. 2012 Feb;26(2):730-7.
  16. Apidianakis Y & Rahme L. Drosophila as a model for human intestinal infection and pathology. Dis Model Mech. 2011 Jan;4(1):21-30.
  17. Apidianakis Y, Pitsouli C, Perrimon N & Rahme LG. Synergy between Bacterial Infection and Genetic Predisposition in Intestinal Dysplasia. Proc Natl Acad Sci USA. 2009 Dec; 106(49):20883-8.
  18. Apidianakis Y & Rahme LG. Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection. Nature Protocols 2009 Aug 13; 4:1285-1294.
  19. Apidianakis Y, Mindrinos, MN Xiao W, Tegos GP, Papisov MI, Hamblin MR, Tompkins RG, Davis RW, and Rahme LG. Involvement of Skeletal Muscle Gene Regulatory Network in Susceptibility to Wound Infection following Trauma. PLoS ONE, 2007 Dec 26;2(12):e1356
  20. Apidianakis Y, Mindrinos MN, Xiao W, Lau GW, Baldini RL, Davis RW, Rahme LG. Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression. Proc Natl Acad Sci USA. 2005 Feb;102(7):2573-8.