ΛΕΟΝΤΙΟΣ ΚΩΣΤΡΙΚΗΣ
ΚΩΣΤΡΙΚΗΣ ΛΕΟΝΤΙΟΣ
KOSTRIKIS LEONTIOS
...
PROFESSOR
Department of Biological Sciences
FST 02 - Faculty of Pure and Applied Sciences
University Campus
B170
+35722892885
+35722895096
www.kostrikislab.com

Προσωπικό Προφίλ

Dr. Leondios Kostrikis is a tenured Professor of Biotechnology and Virology at University of Cyprus, Head of Laboratory of Biotechnology and Molecular Virology and Vice-Chairperson of the Department of Biological Sciences. He received his B.Sc. (1987), M.Sc. (1989), M.Ph. (1990) and Ph.D. (1993) degrees from New York University (NYU), United States. This was followed by post-doctoral research at the Aaron Diamond AIDS Research Center of Rockefeller University (New York) on the molecular virology of human immunodeficiency virus. He joined the faculty of the Aaron Diamond AIDS Research Center as a staff investigator in 1998 and the Rockefeller University as an Assistant Professor in 1999. He moved to Cyprus in 2003, joining the University of Cyprus.
 
He was a Fulbright Scholar for his undergraduate studies at NYU (1983-1987) and has held fellowship awards from the Elizabeth Glazer Pediatric AIDS Foundation, the Aaron Diamond Foundation and the Patti Birch 1991 Trust, United States. He has directed over twenty competitive research grants from the US National Institutes of Health (NIH), the European Commission, international charitable foundations and the Cyprus Research Promotion Foundation (CRPF). He is an Editorial Board member for seven international journals, and has served on study sections and committees for European and international grant agencies, charities, and scientific conferences in HIV/AIDS. He is a co-founder and Executive Board member of the European Society for Translational Antiviral Research (ESAR) and member of Board of Directors of the Takis & Louki Nemitsas Foundation. In 2019, he was elected as a Founding Member (Biological Sciences) of the Cypriot Academy of Sciences, Letters and Arts. 
Dr. Kostrikis is an internationally recognized scientist in the field of HIV/AIDS, who has made important indepentent contributions to the study of human genetics in the transmission of HIV-1 and disease progression, global molecular epidemiology of HIV-1 infection, and HIV-1 drug resistance. His laboratory continues to work on HIV-1 transmission and pathogenesis and how host and viral factors may influence the progression of the disease; studying the mechanisms of drug resistance development during HIV antiretroviral therapy; understanding the implications of natural genetic diversity in efficacy of antiretroviral drugs; studying the molecular phylogeography of HIV-1 and HCV infection in Europe; and developing novel HIV-1 immonogens and vaccination strategies for mucosal and systemic immunity. Dr. Kostrikis has now turned his attention to novel concepts in HIV vaccine development and prevention of HIV-1 transmission.
  1. Demetriou V. L, van de Vijver D. A. M. C., Kousiappa I., Balotta C., Clotet B., Grossman Z., Jorgensen L. B., Lepej S. Z., Levy I., Nielsen C., Paraskevis D., Poljak M., Roman F., Ruiz L., Schmidt J-C., Vandamme A-M., Van Laethem K., Vercauteren J. and Kostrikis L.G. Cellular HIV-1 DNA Levels in Drug Sensitive Strains are Equivalent to Those in Drug Resistant Rtrains in Newly-Diagnosed Patients in Europe. PLoS One 5(6) e10976, 2010
  2. Loizidou E., Kousiappa I., Themistocleous G., Zeinalipour-Yazdi C. D., van de Vijver D. A. M. C. and Kostrikis L. G. Implications of HIV-1 M-Group Polymorphisms on Integrase Inhibitor Efficacy and Resistance: Genetic and Structural in-silico Analysis. Biochemistry 48(1): 4-6, 2009.
  3. Metzner K. J., Bonhoeffer S., Fischer M., Karanicolas R., Allers K., Joos B., Weber R., Hirschel B., Kostrikis L. G. Gunthard H. Emergence of Minor Populations of Human Immunodefieciency Virus Type 1 Carrying the M184V and L90M Mutations in Subjects Undergoing Structured Treatment Interruptions. J. Infect. Diseases 188(10): 1433-1443, 2003
  4. Kostrikis L. G., Touloumi G., Karanicolas R., Pantazis N., Anastassopoulou C., Karafoulidou A., Goedert J. J., Hatzakis A. Quantitation of Human Immunodeficiency Virus Type I DNA Forms with the Second Template Switch in Peripheral Blood Predicts Disease Progression Independently of Plasma RNA Load. J. Virology 76 (20): 10099-10108, 2002
  5. Valentin A., Rosati M., Patenaude D. J., Hatzakis A., Kostrikis L.G., Lazanas M., Wyvill K. M., Yarchoan R., Pavlakis G. N. Persistent HIV-1 Infection of Natural Killer Cells in Patients Receiving Highly Active Anti-Retroviral Therapy. Proc Natl Acad Sci USA 99 (10): 7015-7020, 2002.
  6. Hatzakis A., Touloumi G., Karanicolas R., Anastassopoupou C., Karafoulidou A., Mandalaki T., Goedert J. J., Zhang L., Ho D. D., Kostrikis L. G. Effect of Recent Thymic Emigrants on Progression of HIV-1 Disease. Lancet 355 (9204): 599-604, 2000
  7. Sharkey M., Teo I., Greenough T., Sharova N., Luzuriaga K., Sullivan J. L., Bucy P., Kostrikis L. G., Davaro R., Cheeseman S., Daly J., Bova C., Ellison D., Mady B., Lai K. K., Moyle G., Nelson M., Gazzard B., Shaunak S., Stevenson M. Persistense of Episomal HIV-1 Infection Intermediates in Patients on Active Anti-Retroviral Therapy. Nature Medicine 6 (1): 76-81, 2000
  8. Kostrikis, L. G., Neumann A. U., Thomson B., Korber T. B., McHarty P. G., Karanicolas R., Deutsch L., Huang Y., Lew J. F., Mcintosh K., Pollack H., Borkowsky W., Spiegel H. M. L., Palumbo P., Oleske J., Bardequez A., Luzuriaga K., Sullivan L. J., Wolinsky S. M., Koup R. A., Ho D. D., Moore J. P. A Polymorphism in the Regulatory Regions of the CC-Chemokine Receptor 5 Gene Influences Perinatal Transmission of Human Immunodeficiency Virus Type 1 to African-American Infants. J. Virology 73 (12): 10264-10271, 1999
  9. Zhang, L., Lewin S., Markowitz M., Lin H-H., Skulsky E., Karanicolas R., He Y., Jin X., Tuttleton S., Vesamen M., Spiegel H., Kost R., Wolinsky S., Borkowsky W., Palumbo P., Kostrikis L. G., Ho D. D. Measuring Recent Thymic Emigrants in Blood of Normal Persons and HIV-1-Infected Patients Before and After Effective Therapy. J. Exp. Medicine 190 (5): 725-732, 1999
  10. Jin, X., Bauer D. E., Tuttleton S. E., Lewin S., Gettie A., Kostrikis L. G., Blanchard J., Irwin C. E., Safrit J. T., Zhang L., Ho D. D. Dramatic Rise in the Plasma Viremia after CD8+ T-cell Depletion in SIV-Infected macaques. J. Exp. Medicine 189 (12): 991-998, 1999
  11. Kostrikis L. G., Huang Y., Moore J. P., Wolinsky S. M., Zhang L., Guo Y., Deutsch L., Phair J., Neumann A. U., Ho D. D. A Chemokine Receptor CCR2 Allele Delays HIV-1 Disease Progression and is Associated with a CCR5 Promoter Mutation. Nature Medicine 4 (3): 350-353, 1998
  12. Kostrikis L. G., Tyagi S., Mhlanga M., Ho D. D., Kramer R. F. Spectral Genotyping of Human Alleles. Science 279 (5354): 1228-1229, 1998
  13. Kostrikis L. G., Cao Y., Ngai H., Moore J. P., Ho D. D. A Quantitative Analysis of Serum Neutralization of Human Immunodeficiency Virus Type 1 from Subtypes A, B, C, D, F, and I: Lack of Direct Correlation Between Neutralization Serotypes and Genetic Subtypes and Evidence for Prevalent Serum-Dependent Infectivity Enhancement. J. Virology 70 (1): 445-458, 1996
  14. Kostrikis L. G., Bagdades E., Cao Y., Zhang L., Dimitriou D., Ho D. D. Genetic Analysis of Human Immunodeficiency Virus Type-1 Strains from Patients in Cyprus: Identification of a New Subtype (I). J. Virology 69 (10): 6122-6130, 1995.

Profile Information

Dr. Leondios Kostrikis is a tenured Professor of Biotechnology and Virology at University of Cyprus, Head of Laboratory of Biotechnology and Molecular Virology and Vice-Chairperson of the Department of Biological Sciences. He received his B.Sc. (1987), M.Sc. (1989), M.Ph. (1990) and Ph.D. (1993) degrees from New York University (NYU), United States. This was followed by post-doctoral research at the Aaron Diamond AIDS Research Center of Rockefeller University (New York) on the molecular virology of human immunodeficiency virus. He joined the faculty of the Aaron Diamond AIDS Research Center as a staff investigator in 1998 and the Rockefeller University as an Assistant Professor in 1999. He moved to Cyprus in 2003, joining the University of Cyprus.
 
He was a Fulbright Scholar for his undergraduate studies at NYU (1983-1987) and has held fellowship awards from the Elizabeth Glazer Pediatric AIDS Foundation, the Aaron Diamond Foundation and the Patti Birch 1991 Trust, United States. He has directed over twenty competitive research grants from the US National Institutes of Health (NIH), the European Commission, international charitable foundations and the Cyprus Research Promotion Foundation (CRPF). He is an Editorial Board member for seven international journals, and has served on study sections and committees for European and international grant agencies, charities, and scientific conferences in HIV/AIDS. He is a co-founder and Executive Board member of the European Society for Translational Antiviral Research (ESAR) and member of  the Board of Directors of the Takis & Louki Nemitsas Foundation. In 2019, he was elected as a Founding Member (Biological Sciences) of the Cypriot Academy of Sciences, Letters and Arts.
Dr. Kostrikis is an internationally recognized scientist in the field of HIV/AIDS, who has made important indepentent contributions to the study of human genetics in the transmission of HIV-1 and disease progression, global molecular epidemiology of HIV-1 infection, and HIV-1 drug resistance. His laboratory continues to work on HIV-1 transmission and pathogenesis and how host and viral factors may influence the progression of the disease; studying the mechanisms of drug resistance development during HIV antiretroviral therapy; understanding the implications of natural genetic diversity in efficacy of antiretroviral drugs; studying the molecular phylogeography of HIV-1 and HCV infection in Europe; and developing novel HIV-1 immonogens and vaccination strategies for mucosal and systemic immunity. Dr. Kostrikis has now turned his attention to novel concepts in HIV vaccine development and prevention of HIV-1 transmission.
  1. Demetriou V. L, van de Vijver D. A. M. C., Kousiappa I., Balotta C., Clotet B., Grossman Z., Jorgensen L. B., Lepej S. Z., Levy I., Nielsen C., Paraskevis D., Poljak M., Roman F., Ruiz L., Schmidt J-C., Vandamme A-M., Van Laethem K., Vercauteren J. and Kostrikis L.G. Cellular HIV-1 DNA Levels in Drug Sensitive Strains are Equivalent to Those in Drug Resistant Rtrains in Newly-Diagnosed Patients in Europe. PLoS One 5(6) e10976, 2010
  2. Loizidou E., Kousiappa I., Themistocleous G., Zeinalipour-Yazdi C. D., van de Vijver D. A. M. C. and Kostrikis L. G. Implications of HIV-1 M-Group Polymorphisms on Integrase Inhibitor Efficacy and Resistance: Genetic and Structural in-silico Analysis. Biochemistry 48(1): 4-6, 2009.
  3. Metzner K. J., Bonhoeffer S., Fischer M., Karanicolas R., Allers K., Joos B., Weber R., Hirschel B., Kostrikis L. G. Gunthard H. Emergence of Minor Populations of Human Immunodefieciency Virus Type 1 Carrying the M184V and L90M Mutations in Subjects Undergoing Structured Treatment Interruptions. J. Infect. Diseases 188(10): 1433-1443, 2003
  4. Kostrikis L. G., Touloumi G., Karanicolas R., Pantazis N., Anastassopoulou C., Karafoulidou A., Goedert J. J., Hatzakis A. Quantitation of Human Immunodeficiency Virus Type I DNA Forms with the Second Template Switch in Peripheral Blood Predicts Disease Progression Independently of Plasma RNA Load. J. Virology 76 (20): 10099-10108, 2002
  5. Valentin A., Rosati M., Patenaude D. J., Hatzakis A., Kostrikis L.G., Lazanas M., Wyvill K. M., Yarchoan R., Pavlakis G. N. Persistent HIV-1 Infection of Natural Killer Cells in Patients Receiving Highly Active Anti-Retroviral Therapy. Proc Natl Acad Sci USA 99 (10): 7015-7020, 2002.
  6. Hatzakis A., Touloumi G., Karanicolas R., Anastassopoupou C., Karafoulidou A., Mandalaki T., Goedert J. J., Zhang L., Ho D. D., Kostrikis L. G. Effect of Recent Thymic Emigrants on Progression of HIV-1 Disease. Lancet 355 (9204): 599-604, 2000
  7. Sharkey M., Teo I., Greenough T., Sharova N., Luzuriaga K., Sullivan J. L., Bucy P., Kostrikis L. G., Davaro R., Cheeseman S., Daly J., Bova C., Ellison D., Mady B., Lai K. K., Moyle G., Nelson M., Gazzard B., Shaunak S., Stevenson M. Persistense of Episomal HIV-1 Infection Intermediates in Patients on Active Anti-Retroviral Therapy. Nature Medicine 6 (1): 76-81, 2000
  8. Kostrikis, L. G., Neumann A. U., Thomson B., Korber T. B., McHarty P. G., Karanicolas R., Deutsch L., Huang Y., Lew J. F., Mcintosh K., Pollack H., Borkowsky W., Spiegel H. M. L., Palumbo P., Oleske J., Bardequez A., Luzuriaga K., Sullivan L. J., Wolinsky S. M., Koup R. A., Ho D. D., Moore J. P. A Polymorphism in the Regulatory Regions of the CC-Chemokine Receptor 5 Gene Influences Perinatal Transmission of Human Immunodeficiency Virus Type 1 to African-American Infants. J. Virology 73 (12): 10264-10271, 1999
  9. Zhang, L., Lewin S., Markowitz M., Lin H-H., Skulsky E., Karanicolas R., He Y., Jin X., Tuttleton S., Vesamen M., Spiegel H., Kost R., Wolinsky S., Borkowsky W., Palumbo P., Kostrikis L. G., Ho D. D. Measuring Recent Thymic Emigrants in Blood of Normal Persons and HIV-1-Infected Patients Before and After Effective Therapy. J. Exp. Medicine 190 (5): 725-732, 1999
  10. Jin, X., Bauer D. E., Tuttleton S. E., Lewin S., Gettie A., Kostrikis L. G., Blanchard J., Irwin C. E., Safrit J. T., Zhang L., Ho D. D. Dramatic Rise in the Plasma Viremia after CD8+ T-cell Depletion in SIV-Infected macaques. J. Exp. Medicine 189 (12): 991-998, 1999
  11. Kostrikis L. G., Huang Y., Moore J. P., Wolinsky S. M., Zhang L., Guo Y., Deutsch L., Phair J., Neumann A. U., Ho D. D. A Chemokine Receptor CCR2 Allele Delays HIV-1 Disease Progression and is Associated with a CCR5 Promoter Mutation. Nature Medicine 4 (3): 350-353, 1998
  12. Kostrikis L. G., Tyagi S., Mhlanga M., Ho D. D., Kramer R. F. Spectral Genotyping of Human Alleles. Science 279 (5354): 1228-1229, 1998
  13. Kostrikis L. G., Cao Y., Ngai H., Moore J. P., Ho D. D. A Quantitative Analysis of Serum Neutralization of Human Immunodeficiency Virus Type 1 from Subtypes A, B, C, D, F, and I: Lack of Direct Correlation Between Neutralization Serotypes and Genetic Subtypes and Evidence for Prevalent Serum-Dependent Infectivity Enhancement. J. Virology 70 (1): 445-458, 1996
  14. Kostrikis L. G., Bagdades E., Cao Y., Zhang L., Dimitriou D., Ho D. D. Genetic Analysis of Human Immunodeficiency Virus Type-1 Strains from Patients in Cyprus: Identification of a New Subtype (I). J. Virology 69 (10): 6122-6130, 1995.