ΠΑΝΤΕΛΗΣ ΓΕΩΡΓΙΑΔΗΣ
ΓΕΩΡΓΙΑΔΗΣ ΠΑΝΤΕΛΗΣ
GEORGIADES PANTELIS
...
ASSOCIATE PROFESSOR
Department of Biological Sciences
FST 02 - Faculty of Pure and Applied Sciences
University Campus
036
22892888
-
pantelisgeorgiades.wix.com/thegeorgiadeslab

Προσωπικό Προφίλ

Dr Pantelis Georgiades is currently an Assistant Professor and head of the 'Embryology and Stem cells' research Lab at the 'Department of Biological Sciences' of the 'University of Cyprus'. He obtained his BSc. Hons degree from the School of Biological Sciences of 'Queen Mary, University of London' (UK) with a scholarship for undergraduate research from the 'Gatsby Charitable Foundation'. He then obtained his PhD degree in 'Developmental Biology' (from research in Prof. Paul Brickell's Lab) from the Department of 'Molecular Pathology' at 'UCL, University of London' (UK), whilst being a recepient of scholaships from the 'Wellcome Trust' and the 'A.G. Leventis Foundation'. Subsequently, Dr Georgiades carried our research in 'Embryology, Placentology and Epigenetics' as a postdoctoral Fellow (scholarship from the 'Wellcome Trust') at the 'Department of Anatomy' (with Prof. Anne Ferguson-Smith and Prof. Graham Burton) of the 'University of Cambridge' (UK). He then carried out research with Prof. Janet Rossant in 'Extraembryonic tissues and Stem cells', whilst receiving a scholarship from the 'Samuel Lunenfeld Research Institute' of 'Mount Sinai Hospital' (Canada). Dr Georgiades has published in several peer-reviewed scientific journals including “Proceedings of the National Academy of Sciences of the United States of America (PNAS)”, “Development”, “Placenta” και “Nature Communications”.
Our Lab aims to understand unknown, but medically significant, aspects of embryonic development: The amazing self-transformation of the fertilized egg (a small-sized and relatively simple structure without any tissues or organs) into the conceptus (foetus + extraembryonic tissues), which is much larger, increadibly more complex and contains all tissues and organs.Our current research objectives are to understand the genetic and cellular basis of:(a) The influence of extraembryonic tissues on early embryo patterning, gastrulation, organogenesis and viability.(b) The development and function of extraembryonic tissues (and their stem cells) with emphasis on the placenta.(c) Feto-maternal interactions in the placental and their effect on foetal growth/viability and the pregnant mother.
• Polydorou C, Georgiades P* (2013). Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nature communications, 4, 1658.• Charalambous C, Drakou K, Nicolaou, S, Georgiades P* (2013). Novel spatiotemporal glycome changes in the murine placenta during placentation based on BS?I lectin binding patterns. Anatοmical Record 296, 921-932.• Charalambous F, Elia A, Georgiades P* (2012) Decidual spiral artery remodeling during early post-implantation period in mice: Investigation of associations with decidual uNK cells and invasive trophoblast. Biochem Biophys Res Commun. 417, 847-852.• Elia A, Charalambous F, Georgiades P* (2011) New phenotypic aspects of the decidual spiral artery wall during early post-implantation mouse pregnancy. Biochem Biophys Res Commun. 416, 211-216.• Odiatis C, Georgiades P* (2010) New insights for Ets2 function in trophoblast using lentivirus-mediated gene knockdown in trophoblast stem cells. Placenta 31, 630-640. • Georgiades P*, Cox B, Gertsenstein M, Chawengsaksophak K, Rossant J (2007) Trophoblast-specific gene manipulation using lentivirus-based vectors. BioTechniques 42, 317-325. • Georgiades P and Rossant J (2006) Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development. Development 133, 1059-1068. • Georgiades P* (2004) The possible clinical relevance of mouse placental research. SICC (Invited expert section), 17-12-2004.• Georgiades P*, Ferguson-Smith AC, Burton GJ (2002) Comparative developmental anatomy of murine and human definitive placentae. Placenta 23, 3-19. • Georgiades P, Ogilvy S, Duval H, Licence DR, Charnock-Jones DS, Smith SK, Print CG (2002) VavCre transgenic mice: a tool for mutagenesis in hematopoietic and endothelial lineages. Genesis 34, 251-6. • Georgiades P, Watkins M, Burton GJ, Ferguson-Smith AC (2001) Roles for genomic imprinting and the zygotic genome in placental development. Proceedings of the National Academy of Sciences USA 98, 4522-4527. • Ferguson-Smith AC, Tevendale M, Georgiades P, Grandjean (2001) Balanced translocations for the analysis of imprinted regions of the mouse genome. Methods in Molecular Biology 181, 41-54. • Georgiades P, Watkins M, Surani MA, Ferguson-Smith AC (2000) Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12. Development 127, 4719-28. • Takada S, Tevendale M, Baker J, Georgiades P, Campbell E, Freeman T, Johnson MH, Paulsen M, Ferguson-Smith AC (2000) Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12. Current Biology 10, 1135-8. • Georgiades P, Chierakul C,Ferguson-Smith AC (1998)Parental origin effects in human trisomy for chromosome14q: implications for genomic imprinting.Journal of Medical Genetics 35, 821 824. • Georgiades P*, Wood J, Brickell PM (1998) Retinoid X receptor-gamma gene expression is developmentally regulated in the embryonic rodent peripheral nervous system. Anatomy and Embryology 197, 477-484. • Georgiades P* and Brickell PM (1998) Regulation of retinoid X receptor-gamma gene transcript levels in rat heart cells. Cell Biology International 22, 457-463. • Georgiades P* and Brickell PM (1997) Differential expression of the rat retinoid X receptor gamma gene during skeletal muscle differentiation suggests a role in myogenesis. Developmental Dynamics 210,1-10. • Georgiades P, Kieszkiewicz J, Rozyca M, Brickell PM, Lund T (1996) Coexpression of H2-Mb and H2-Ab genes during fetal and postnatal development. Immunology 88, 447-451.

Profile Information

Dr Pantelis Georgiades is currently an Assistant Professor and head of the 'Embryology and Stem cells' research Lab at the 'Department of Biological Sciences' of the 'University of Cyprus'. He obtained his BSc. Hons degree from the School of Biological Sciences of 'Queen Mary, University of London' (UK) with a scholarship for undergraduate research from the 'Gatsby Charitable Foundation'. He then obtained his PhD degree in 'Developmental Biology' (from research in Prof. Paul Brickell's Lab) from the Department of 'Molecular Pathology' at 'UCL, University of London' (UK), whilst being a recepient of scholaships from the 'Wellcome Trust' and the 'A.G. Leventis Foundation'. Subsequently, Dr Georgiades carried our research in 'Embryology, Placentology and Epigenetics' as a postdoctoral Fellow (scholarship from the 'Wellcome Trust') at the 'Department of Anatomy' (with Prof. Anne Ferguson-Smith and Prof. Graham Burton) of the 'University of Cambridge' (UK). He then carried out research with Prof. Janet Rossant in 'Extraembryonic tissues and Stem cells', whilst receiving a scholarship from the 'Samuel Lunenfeld Research Institute' of 'Mount Sinai Hospital' (Canada). Dr Georgiades has published in several peer-reviewed scientific journals including “Proceedings of the National Academy of Sciences of the United States of America (PNAS)”, “Development”, “Placenta” και “Nature Communications”.
Our Lab aims to understand unknown, but medically significant, aspects of embryonic development: The amazing self-transformation of the fertilized egg (a small-sized and relatively simple structure without any tissues or organs) into the conceptus (foetus + extraembryonic tissues), which is much larger, increadibly more complex and contains all tissues and organs.Our current research objectives are to understand the genetic and cellular basis of:(a) The influence of extraembryonic tissues on early embryo patterning, gastrulation, organogenesis and viability.(b) The development and function of extraembryonic tissues (and their stem cells) with emphasis on the placenta.(c) Feto-maternal interactions in the placental and their effect on foetal growth/viability and the pregnant mother.
• Polydorou C, Georgiades P* (2013). Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nature communications, 4, 1658.• Charalambous C, Drakou K, Nicolaou, S, Georgiades P* (2013). Novel spatiotemporal glycome changes in the murine placenta during placentation based on BS?I lectin binding patterns. Anatοmical Record 296, 921-932.• Charalambous F, Elia A, Georgiades P* (2012) Decidual spiral artery remodeling during early post-implantation period in mice: Investigation of associations with decidual uNK cells and invasive trophoblast. Biochem Biophys Res Commun. 417, 847-852.• Elia A, Charalambous F, Georgiades P* (2011) New phenotypic aspects of the decidual spiral artery wall during early post-implantation mouse pregnancy. Biochem Biophys Res Commun. 416, 211-216.• Odiatis C, Georgiades P* (2010) New insights for Ets2 function in trophoblast using lentivirus-mediated gene knockdown in trophoblast stem cells. Placenta 31, 630-640. • Georgiades P*, Cox B, Gertsenstein M, Chawengsaksophak K, Rossant J (2007) Trophoblast-specific gene manipulation using lentivirus-based vectors. BioTechniques 42, 317-325. • Georgiades P and Rossant J (2006) Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development. Development 133, 1059-1068. • Georgiades P* (2004) The possible clinical relevance of mouse placental research. SICC (Invited expert section), 17-12-2004.• Georgiades P*, Ferguson-Smith AC, Burton GJ (2002) Comparative developmental anatomy of murine and human definitive placentae. Placenta 23, 3-19. • Georgiades P, Ogilvy S, Duval H, Licence DR, Charnock-Jones DS, Smith SK, Print CG (2002) VavCre transgenic mice: a tool for mutagenesis in hematopoietic and endothelial lineages. Genesis 34, 251-6. • Georgiades P, Watkins M, Burton GJ, Ferguson-Smith AC (2001) Roles for genomic imprinting and the zygotic genome in placental development. Proceedings of the National Academy of Sciences USA 98, 4522-4527. • Ferguson-Smith AC, Tevendale M, Georgiades P, Grandjean (2001) Balanced translocations for the analysis of imprinted regions of the mouse genome. Methods in Molecular Biology 181, 41-54. • Georgiades P, Watkins M, Surani MA, Ferguson-Smith AC (2000) Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12. Development 127, 4719-28. • Takada S, Tevendale M, Baker J, Georgiades P, Campbell E, Freeman T, Johnson MH, Paulsen M, Ferguson-Smith AC (2000) Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12. Current Biology 10, 1135-8. • Georgiades P, Chierakul C,Ferguson-Smith AC (1998)Parental origin effects in human trisomy for chromosome14q: implications for genomic imprinting.Journal of Medical Genetics 35, 821 824. • Georgiades P*, Wood J, Brickell PM (1998) Retinoid X receptor-gamma gene expression is developmentally regulated in the embryonic rodent peripheral nervous system. Anatomy and Embryology 197, 477-484. • Georgiades P* and Brickell PM (1998) Regulation of retinoid X receptor-gamma gene transcript levels in rat heart cells. Cell Biology International 22, 457-463. • Georgiades P* and Brickell PM (1997) Differential expression of the rat retinoid X receptor gamma gene during skeletal muscle differentiation suggests a role in myogenesis. Developmental Dynamics 210,1-10. • Georgiades P, Kieszkiewicz J, Rozyca M, Brickell PM, Lund T (1996) Coexpression of H2-Mb and H2-Ab genes during fetal and postnatal development. Immunology 88, 447-451.