Ειρήνη Χριστάκη
ΧΡΙΣΤΑΚΗ ΕΙΡΗΝΗ
-
...
LECTURER
Medical School
Shiakoleion Educational Health Center (SEKY)
215/6 Nicosia - Limassol Old Road
117
+35722895225
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http://www.ucy.ac.cy/medical/en/

Προσωπικό Προφίλ

ΣΠΟΥΔΕΣ ΚΑΙ ΕΙΔΙΚΕΥΣΗ

 

2001              Πτυχίο Ιατρικής, Τμήμα Ιατρικής, Σχολή Επιστημών Υγείας, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης

2004-2007      Ειδικότητα Παθολογίας, Jacobi Medical Center, Albert Einstein College of Medicine, ΝΥ, ΗΠA

2007              American Board of Internal Medicine Certification

2007-2009      Eξειδίκευση στη Λοιμωξιολογία, Alpert Medical School of Brown University, Providence, RI, ΗΠΑ

2009              American Board of Internal Medicine Certification (Subspecialty Board of Infectious Diseases)

2010-2011      Ειδικότητα Παθολογίας, Β΄Προπαιδευτική Παθολογική Κλινική, ΓΝΘ Ιπποκράτειο, Ελλάδα

2009-2012      Διδακτορική Διατριβή, Τμήμα Ιατρικής, Σχολή Επιστημών Υγείας, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης  

 

ΚΛΙΝΙΚΗ ΕΜΠΕΙΡΙΑ

 

2016-2018   Ειδική Παθολόγος-Λοιμωξιολόγος, Γενικό Νοσοκομείο Λευκωσίας

2016            Πανεπιστημιακή Υπότροφος του Ιατρικού Τμήματος ΑΠΘ, Α΄ Παθολογική Κλινική, Π.Γ.Ν.Θ. ΑΧΕΠΑ

2013-2015   Παθολόγος – Λοιμωξιολόγος

                    Κέντρο Ελέγχου και Πρόληψης Νοσημάτων (ΚΕΕΛΠΝΟ), Α΄Παθολογική Κλινική Α. Π. Θ

2012-2013   Επικουρική Ιατρός, Ειδικός Παθολόγος, Παθολογική Κλινική Γ.Ν.Θ. Άγιος Πάύλος

 

ΔΙΔΑΚΤΙΚΗ ΕΜΠΕΙΡΙΑ

2016- σήμερα Διδασκαλία του μαθήματος Παθολογία στο 4 έτος και στο 6ο έτος (Κλινική Εκπαίδευση και Θεωρητικές Διαλέξεις)

2013-2016 - Διδασκαλία του μαθήματος «Εσωτερική Παθολογία» (ΣΤ΄, Θ΄, και ΙΑ΄- ΙΒ εξάμηνα), Α΄ Παθολογική Κλινική Α. Π. Θ. Εκπαίδευση των ειδικευόμενων Παθολογίας και των εξειδικευόμενων στη Λοιμωξιολογία

2012-2016 - Διδασκαλία του επιλεγόμενου μαθήματος «Τροπικά Νοσήματα-Νοσοκομειακές- Λοιμώξεις», Γ΄ Παθολογική Κλινική Α.Π.Θ

2009-2016 - Διδασκαλία του επιλεγόμενου μαθήματος «Εργαστήριο Κλινικών Δεξιοτήτων» και υπεύθυνη του μαθήματος «Πρόληψη Λοιμώξεων» Εργαστήριο Υγιεινής Ιατρικού Τμήματις Α.Π.Θ.

2010 - Συμβασιούχος Λέκτορας σύμφωνα με το Π.Δ. 407/80 στην Ιατρική Σχολή του Α.Π.Θ. (αριθμ.46932/15-04-2010 Πρυτανική
Πράξη). Διδασκαλία στο μάθημα «Παθολογία»

 

 

 

 

 

 

 

 

  • Συμμετοχή ως ερευνήτρια σε διεθνείς  κλινικές μελέτες (CARE-ACHN, PRATEK, TANGO-REMPEX, AIDA, SPECIFY, EXTEND, INSIGHT-FLU) που αφορούν στην χρήση νέων αντιμικροβιακών στις λοιμώξεις καθώς και την επιδημιολογία και την παθοφυσιολογία ιογενών και βακτηριακών λοιμώξεων. Κλινική έρευνα με αντικείμενο τις λοιμώξεις από πολυανθεκτικά μικρόβια, την πρόληψη και τον έλεγχο των νοσοκομειακών λοιμώξεων, την σήψη και HIV λοίμωξη. (Α' Παθλογική Κλινική Α.Π.Θ.)
  • Ο ρόλος των NK και NKT κυττάρων στην άμυνα του ξενιστή έναντι βακτηριακών παθογόνων σε μοντέλα πειραματοζώων με σήψη. (Διδακτορική Διατριβή)
  • Μελέτη της δράσης των αγωνιστών του β-υποδοχέα των οιστρογόνων και της δράσης anti-RAGE αντισωμάτων σε πειραματική βακτηριακή σήψη. (Alpert Medical School of Brown University, Division of Infectious Diseases Providence, RI, ΗΠΑ, Mentor: Prof. Steven Opal)
  • Μελέτη της δράσης αντιμυκητιασιακών και μονοκλωνικών αντισωμάτων έναντι βιοϋμενίων από το μύκητα κρυπτόκοκκο. (Albert Einstein College of Medicine, Department of Microbiology and Immunology, NY, NY, ΗΠΑ, Mentor: Prof. Arturo Casadevall)

 

  • Πλήρεις δημοσιεύσεις σε διεθνή περιοδικά (peer-reviewed, indexed in PubMed) 21
  • Βιβλιογραφικές αναφορές 262 (scopus)
  • h factor 10 (Scopus)
  • Περιλήψεις σε διεθνή περιοδικά 8
  • Περιλήψεις σε τόμους διεθνών συνεδρίων 24
  • Περιλήψεις σε τόμους ελληνικών συνεδρίων 16
  • Κεφάλαια σε ξενόγλωσσα βιβλία 1
  • Κεφάλαια σε διδακτικά βιβλία 2
  • Εισηγήσεις σε συνέδρια, ημερίδες, μετεκπαιδευτικά σεμινάρια >30

 

  1. Konstantinou E., Christaki E. Pitsios C. Daily dose of itraconazole 100 mg to treat allergic bronchopulmonary aspergillosis (ABPA) related eosinophilia: a case report. November 2018Hippokratia 21(3):144-146
  2. Voskarides K, Christaki E, Nikolopoulos GK.Influenza Virus-Host Co-evolution. A Predator-Prey Relationship? Front Immunol. 2018 Sep 7;9:2017
  3. Kachrimanidou M, Tsachouridou O, Ziogas IA, Christaki E, Protonotariou E, Metallidis S, Skoura L, Kuijper E. Clostridium difficile infections in a university hospital in Greece are mainly associated with PCR ribotypes 017 and 126. J Med Microbiol. 2017 Dec;66(12):1774-1781.
  4. Tsachouridou O, Christaki E, Skoura L, Georgiou A, Nanoudis S, Vasdeki D, Ntziovara MA, Kotoreni G, Forozidou E, Tsoukra P, Germanidis G, Metallidis S. Predictors of humoral response to recommended vaccines in HIV-infected adults. Comp Immunol Microbiol Infect Dis. 2017 Oct;54:27-33 
  5. Nikolopoulos G, Christaki E, Paraskevis D, Bonovas S. Pre-Exposure Prophylaxis for HIV: Evidence and Perspectives. Current Pharmaceutical Design. 2017;23(18):2579-2591.
  6. Tsachouridou O, Skoura L, Christaki E, Kollaras P, Sidiropoulou M, Zebekakis P, Vakirlis E, Margariti A, Metallidis S. Syphilis on the rise: A prolonged outbreak of syphilis among HIV infected patients in Northern Greece. GERMS. 2016 vol: 6 (3) pp: 82-90
  7. Christaki E, Diza E, Giamarellos-Bourboulis EJ, Papadopoulou N, Pistiki A, Droggiti DI, et al. NK and NKT Cell Depletion Alters the Outcome of Experimental Pneumococcal Pneumonia: Relationship with Regulation of Interferon-gamma Production. J Immunol Res. 2015;2015:532717.
  8. Christaki E. New technologies in predicting, preventing and controlling emerging infectious diseases. Virulence. 2015:1-8.
  9. Christaki E, Giamarellos-Bourboulis EJ. The Beginning of Personalized Medicine in Sepsis: Small steps to a bright future. Clinical genetics. 2014.
  10. Christaki E, Giamarellos-Bourboulis EJ. The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host. Virulence. 2013;5(1). Epub 2013/09/27
  11. Christaki E. Personalized medicine in sepsis: the coming of age. Expert review of anti-infective therapy. 2013;11(7):645-7. Epub 2013/07/25
  12. Athyros VG, Tziomalos K, Katsiki N, Gossios TD, Giouleme O, Anagnostis P, et al. The impact of smoking on cardiovascular outcomes and comorbidities in statin-treated patients with coronary artery disease: a post hoc analysis of the GREACE study. Current vascular pharmacology. 2013;11(5):779-84.
  13. Christaki, E, N. Lazaridis, Opal SM. Receptor for advanced glycation end products in bacterial infection: is there a role for immune modulation of receptor for advanced glycation end products in the treatment of sepsis? Curr Opin Infect Dis 2012;25(3):304-11
  14. Christaki E, Anyfanti P, Opal SM Immunomodulatory therapy in sepsis: an update. Expert Rev Anti Infect Ther. 2011 Nov;9(11):1013-33.
  15. Christaki E, Opal SM, Keith JC JR, Kessimian N, Palardy JE, Parejo NA, Tan XY, Piche-Nicholas N, Tchistiakova L, Vlasuk GP, Shields KM, Feldman JL, LaVallie ER, Arai M, Mounts W, Pittman DD. A Monoclonal Antibody Against RAGE Alters Gene Expression and is Protective in Experimental Models of Sepsis and Pneumococcal Pneumonia. Shock. 2011;35(5):492-8
  16. Christaki E, Kabaroudis, A, Anagnostou, E, Athyros VG Spontaneous abscesses of the spleen in an immunocompetent adult: Case report and review of the literature. International Journal of Case Reports and Images 2011;2(11):1-5
  17. Athyros VG, Tziomalos K, Gossios TD, Griva T, Anagnostis P, Kargiotis K, Pagourelias ED, Theocharidou E, Karagiannis A, Mikhailidis DP, GREACE Study Collaborative Group: Baharoudis G, Basdekas S, Bouloukos V, Christaki E, Dimopoulou S, Hartamba E, Kakafika A, Kapousouzi M, Koumaras H, Mitsiou E, Papageorgiou A, Pehlivanidis A, Petridis D, Sekeri Z, Skaperdas A, Symeonidis A. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis. Lancet. 2010 Dec 4;376(9756):1916-22.
  18. Christaki E, Patrozou E. The kinetics of T regulatory cells in shock: beyond sepsis. Crit Care. 2010;14(2):132
  19. Christaki E, Opal SM, Keith JC Jr, Kessinian N, Palardy JE, Parejo NA, Lavallie E, Racie L, Mounts W, Malamas MS, Mewshaw RE, Harris HA, Vlasuk GP. Estrogen Receptor beta (ERb) Agonism Increases Survival in Experimentally Induced Sepsis and ameliorates the genomic sepsis signature: A pharmacogenomic study. J Infect Dis. 2010 Apr 15;201(8):1250-7.
  20. Christaki E. Host immune response in sepsis due to ventilator-associated pneumonia: how is it different? Crit Care. 2009;13(6):1009.
  21. Christaki E and Opal SM. Is The Mortality Rate For Septic Shock Really Decreasing? Curr Opin Crit Care. 2008 Oct;14(5):580-6.
  22. Martinez LR, Christaki E, Casadevall A. Specific antibody to Cryptococcus neoformans glucurunoxylomannan antagonizes antifungal drug action against cryptococcal biofilms in vitro. J Infect Dis. 2006 Jul 15;194(2):261-6.

Profile Information

EDUCATION AND TRAINING
 
2001              Medical Degree, Medical School, Aristotle University of Thessaloniki
2004-2007      Intrenal Medicine Residency, Jacobi Medical Center, Albert Einstein College                          of Medicine, ΝΥ, USA
2007              American Board of Internal Medicine Certification
2007-2009      Infectious Diseases Fellowship, Alpert Medical School of Brown University,                           Providence, RI, USA
2009              American Board of Internal Medicine Certification (Subspecialty Board of                                Infectious Diseases)
2009-2012      PhD, Medical School, Aristotle University of Thessaloniki
 
ACADEMIC APPOINTMENTS - TEACHING EXPERIENCE
 
  • September 2016 to present
    • Lecturer in Internal Medicine, Medical School
    • Courses: Internal Medicine (4th year), Internal Medicine (6th year), Clinical Skills (4 year)
  • March 2016 to August 2016
    • Academic Clinical and Research Fellow, First Department of Internal Medicine Aristotle University of Thessaloniki Medical School
    • Teaching the course «Internal Medicine»
  • November 2013 to November 2015
    • First Department of Internal Medicine, Aristotle University of Thessaloniki Medical School
    • Teaching Medical students (Internal Medicine), Internal Medicine residents and Infectious Diseases fellows.
  • May 2012 to August 2016
    • Third Department of Internal Medicine, Aristotle University of Thessaloniki Medical School, Papageorgiou General Hospital
    • Teaching the course «Tropical Diseases-Nosocomial Infections» 
  • October 2009 to August 2016
    • Aristotle University of Thessaloniki, Department of Hygiene
    • Teaching and coordinator of the course «Cinical Skills Lab - Infection Prevention» Clinical Skills Lab
  • April 2010 to August 2010
    • Part-time Lecturer in Internal Medicine (P.D. 407/80) Aristotle University of Thessaloniki
  • October 2009 to present
    • Research Associate in Medicine, Alpert Medical School of Brown University, Providence, RI, USA
  • September 2009 to September 2011
    • Research Associate in Clinical Microbiology, AHEPA Hospital, Microbiology Lab, Aristotle University of Thessaloniki
    • Participation in the educational curriculum of Biopathology Residents.
 
CLINICAL EXPERIENCE
 
  • March 2017 to present
    • Internal Medicine Specialist, Department of Medicine, Nicosia General Hospital
    • Infectious Diseases Consultant, Nicosia General Hospital
  • March 2016 to August 2016
    • Academic Clinical and Research Fellow, Aristotle University of Thessaloniki Medical School
    • Internal Medicine-Infectious Diseases with emphasis on the management of nosocomial infections and HIV infection
    • First Department of Internal Medicine AHEPA University Hospital, Thessaloniki, Greece
  • November 2015 to February 2016
    • Infectious Diseases Consultant
    • First Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece
  • November 2013 to November 2015
    • Infectious Diseases Consultant, Hellenic Center for Disease Control and Prevention (KEELPNO)
    • First Department of Internal Medicine AHEPA University Hospital, Thessaloniki, Greece
  • March 2012 to March 2013 
    • Internal Medicine Specialist
    • Department of Internal Medicine Agios Pavlos General Hospital of Thessaloniki
Research Interests:
  • Personalized approach in the management of sepsis.
  • Host-pathogen interactions and infectious disease pathogenesis.
  • Healthcare-associated infections and antimicrobial resistance.
  • Novel antimicrobials in the treatment of severe bacterial infections.
  • The role of innate immune cells in sepsis. Immunology of Infectious Diseases.
  • HIV infection
 
 
  • Publications in peer-reviewed journals 22
  • Citations 262
  • h-index 10 (Scopus)
  1. Konstantinou E., Christaki E. Pitsios C. Daily dose of itraconazole 100 mg to treat allergic bronchopulmonary aspergillosis (ABPA) related eosinophilia: a case report. November 2018Hippokratia 21(3):144-146
  2. Voskarides K, Christaki E, Nikolopoulos GK.Influenza Virus-Host Co-evolution. A Predator-Prey Relationship? Front Immunol. 2018 Sep 7;9:2017
  3. Kachrimanidou M, Tsachouridou O, Ziogas IA, Christaki E, Protonotariou E, Metallidis S, Skoura L, Kuijper E. Clostridium difficile infections in a university hospital in Greece are mainly associated with PCR ribotypes 017 and 126. J Med Microbiol. 2017 Dec;66(12):1774-1781.
  4. Tsachouridou O, Christaki E, Skoura L, Georgiou A, Nanoudis S, Vasdeki D, Ntziovara MA, Kotoreni G, Forozidou E, Tsoukra P, Germanidis G, Metallidis S. Predictors of humoral response to recommended vaccines in HIV-infected adults. Comp Immunol Microbiol Infect Dis. 2017 Oct;54:27-33 
  5. Nikolopoulos G, Christaki E, Paraskevis D, Bonovas S. Pre-Exposure Prophylaxis for HIV: Evidence and Perspectives. Current Pharmaceutical Design. 2017;23(18):2579-2591.
  6. Tsachouridou O, Skoura L, Christaki E, Kollaras P, Sidiropoulou M, Zebekakis P, Vakirlis E, Margariti A, Metallidis S. Syphilis on the rise: A prolonged outbreak of syphilis among HIV infected patients in Northern Greece. GERMS. 2016 vol: 6 (3) pp: 82-90
  7. Christaki E, Diza E, Giamarellos-Bourboulis EJ, Papadopoulou N, Pistiki A, Droggiti DI, et al. NK and NKT Cell Depletion Alters the Outcome of Experimental Pneumococcal Pneumonia: Relationship with Regulation of Interferon-gamma Production. J Immunol Res. 2015;2015:532717.
  8. Christaki E. New technologies in predicting, preventing and controlling emerging infectious diseases. Virulence. 2015:1-8.
  9. Christaki E, Giamarellos-Bourboulis EJ. The Beginning of Personalized Medicine in Sepsis: Small steps to a bright future. Clinical genetics. 2014.
  10. Christaki E, Giamarellos-Bourboulis EJ. The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host. Virulence. 2013;5(1). Epub 2013/09/27
  11. Christaki E. Personalized medicine in sepsis: the coming of age. Expert review of anti-infective therapy. 2013;11(7):645-7. Epub 2013/07/25
  12. Athyros VG, Tziomalos K, Katsiki N, Gossios TD, Giouleme O, Anagnostis P, et al. The impact of smoking on cardiovascular outcomes and comorbidities in statin-treated patients with coronary artery disease: a post hoc analysis of the GREACE study. Current vascular pharmacology. 2013;11(5):779-84.
  13. Christaki, E, N. Lazaridis, Opal SM. Receptor for advanced glycation end products in bacterial infection: is there a role for immune modulation of receptor for advanced glycation end products in the treatment of sepsis? Curr Opin Infect Dis 2012;25(3):304-11
  14. Christaki E, Anyfanti P, Opal SM Immunomodulatory therapy in sepsis: an update. Expert Rev Anti Infect Ther. 2011 Nov;9(11):1013-33.
  15. Christaki E, Opal SM, Keith JC JR, Kessimian N, Palardy JE, Parejo NA, Tan XY, Piche-Nicholas N, Tchistiakova L, Vlasuk GP, Shields KM, Feldman JL, LaVallie ER, Arai M, Mounts W, Pittman DD. A Monoclonal Antibody Against RAGE Alters Gene Expression and is Protective in Experimental Models of Sepsis and Pneumococcal Pneumonia. Shock. 2011;35(5):492-8
  16. Christaki E, Kabaroudis, A, Anagnostou, E, Athyros VG Spontaneous abscesses of the spleen in an immunocompetent adult: Case report and review of the literature. International Journal of Case Reports and Images 2011;2(11):1-5
  17. Athyros VG, Tziomalos K, Gossios TD, Griva T, Anagnostis P, Kargiotis K, Pagourelias ED, Theocharidou E, Karagiannis A, Mikhailidis DP, GREACE Study Collaborative Group: Baharoudis G, Basdekas S, Bouloukos V, Christaki E, Dimopoulou S, Hartamba E, Kakafika A, Kapousouzi M, Koumaras H, Mitsiou E, Papageorgiou A, Pehlivanidis A, Petridis D, Sekeri Z, Skaperdas A, Symeonidis A. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis. Lancet. 2010 Dec 4;376(9756):1916-22.
  18. Christaki E, Patrozou E. The kinetics of T regulatory cells in shock: beyond sepsis. Crit Care. 2010;14(2):132
  19. Christaki E, Opal SM, Keith JC Jr, Kessinian N, Palardy JE, Parejo NA, Lavallie E, Racie L, Mounts W, Malamas MS, Mewshaw RE, Harris HA, Vlasuk GP. Estrogen Receptor beta (ERb) Agonism Increases Survival in Experimentally Induced Sepsis and ameliorates the genomic sepsis signature: A pharmacogenomic study. J Infect Dis. 2010 Apr 15;201(8):1250-7.
  20. Christaki E. Host immune response in sepsis due to ventilator-associated pneumonia: how is it different? Crit Care. 2009;13(6):1009.
  21. Christaki E and Opal SM. Is The Mortality Rate For Septic Shock Really Decreasing? Curr Opin Crit Care. 2008 Oct;14(5):580-6.
  22. Martinez LR, Christaki E, Casadevall A. Specific antibody to Cryptococcus neoformans glucurunoxylomannan antagonizes antifungal drug action against cryptococcal biofilms in vitro. J Infect Dis. 2006 Jul 15;194(2):261-6.